Monoclonal helper T cells induce B cell responses to T-independent antigens: Antigen-specific T cells are directly stimulated by activated B cells in the absence of antigen

R. H. DeKruyff, C. Clayberger, H. Cantor

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Efficient B cell responses to most polysaccharide antigens such as TNP-PAA or TNP-Ficoll require factors produced by activated T cells. However, the mechanism of T cell activation during such responses has not been established, because these antigens do not activate T cells, either directly or in conjunction with I-A gene products. We used a panel of antigen-specific monoclonal helper T cells to study T cell activation during the course of such responses. We show that activated I-A-identical B cells directly stimulate these monoclonal T cells, and that this stimulation is in the absence of nominal antigen. The high frequency of inducer cells that are stimulated by activated B cells suggests a major biologic role for this novel pathway of T cell activation.

Original languageEnglish (US)
Pages (from-to)86-90
Number of pages5
JournalJournal of Immunology
Volume134
Issue number1
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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