Monocyte chemoattractant protein-1 correlates with subcortical brain injury in HIV infection

A. B. Ragin; Y. Wu; P. Storey; B. A. Cohen; R. R. Edelman; L. G. Epstein

doi:10.1212/01.wnl.0000208433.34723.65

Monocyte chemoattractant protein-1 correlates with subcortical brain injury in HIV infection

A. B. Ragin^*, Y. Wu, P. Storey, B. A. Cohen, R. R. Edelman, L. G. Epstein

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Various biomarkers have been suggested as associative or predictive of HIV-associated neurocognitive impairment. Plasma levels of monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor α(TNF-α), and hematocrit were evaluated for relationships with diffusion tensor imaging measurements of centrum semiovale, caudate, and putamen. MCP-1 levels correlated with tissue status (mean diffusivity) in all examined regions. Plasma markers were also significantly correlated with anisotropy measurements in centrum semiovale (TNF-α) and putamen (hematocrit).

Original language	English (US)
Pages (from-to)	1255-1257
Number of pages	3
Journal	Neurology
Volume	66
Issue number	8
DOIs	https://doi.org/10.1212/01.wnl.0000208433.34723.65
State	Published - Apr 2006

ASJC Scopus subject areas

Clinical Neurology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1212/01.wnl.0000208433.34723.65

Cite this

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title = "Monocyte chemoattractant protein-1 correlates with subcortical brain injury in HIV infection",

abstract = "Various biomarkers have been suggested as associative or predictive of HIV-associated neurocognitive impairment. Plasma levels of monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor α(TNF-α), and hematocrit were evaluated for relationships with diffusion tensor imaging measurements of centrum semiovale, caudate, and putamen. MCP-1 levels correlated with tissue status (mean diffusivity) in all examined regions. Plasma markers were also significantly correlated with anisotropy measurements in centrum semiovale (TNF-α) and putamen (hematocrit).",

author = "Ragin, {A. B.} and Y. Wu and P. Storey and Cohen, {B. A.} and Edelman, {R. R.} and Epstein, {L. G.}",

note = "Funding Information: The National Institute of Mental Health (MH66705) and the National Institute of Neurological Disorders and Stroke (NS36519 and NS049465) provided funding or support for this study. ",

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doi = "10.1212/01.wnl.0000208433.34723.65",

language = "English (US)",

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T1 - Monocyte chemoattractant protein-1 correlates with subcortical brain injury in HIV infection

AU - Ragin, A. B.

AU - Wu, Y.

AU - Storey, P.

AU - Cohen, B. A.

AU - Edelman, R. R.

AU - Epstein, L. G.

N1 - Funding Information: The National Institute of Mental Health (MH66705) and the National Institute of Neurological Disorders and Stroke (NS36519 and NS049465) provided funding or support for this study.

PY - 2006/4

Y1 - 2006/4

N2 - Various biomarkers have been suggested as associative or predictive of HIV-associated neurocognitive impairment. Plasma levels of monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor α(TNF-α), and hematocrit were evaluated for relationships with diffusion tensor imaging measurements of centrum semiovale, caudate, and putamen. MCP-1 levels correlated with tissue status (mean diffusivity) in all examined regions. Plasma markers were also significantly correlated with anisotropy measurements in centrum semiovale (TNF-α) and putamen (hematocrit).

AB - Various biomarkers have been suggested as associative or predictive of HIV-associated neurocognitive impairment. Plasma levels of monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor α(TNF-α), and hematocrit were evaluated for relationships with diffusion tensor imaging measurements of centrum semiovale, caudate, and putamen. MCP-1 levels correlated with tissue status (mean diffusivity) in all examined regions. Plasma markers were also significantly correlated with anisotropy measurements in centrum semiovale (TNF-α) and putamen (hematocrit).

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Monocyte chemoattractant protein-1 correlates with subcortical brain injury in HIV infection

Abstract

ASJC Scopus subject areas

UN SDGs

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