Monocyte-derived DC maturation strategies and related pathways: A transcriptional view

Luciano Castiello; Marianna Sabatino; Ping Jin; Carol Clayberger; Francesco M. Marincola; Alan M. Krensky; David F. Stroncek

doi:10.1007/s00262-010-0954-6

Monocyte-derived DC maturation strategies and related pathways: A transcriptional view

Luciano Castiello, Marianna Sabatino, Ping Jin, Carol Clayberger, Francesco M. Marincola, Alan M. Krensky, David F. Stroncek

Research output: Contribution to journal › Review article › peer-review

96 Scopus citations

Abstract

Ex vivo production of highly stimulator mature dendritic cells (DCs) for cellular therapy has been used to treat different pathological conditions with the aim of inducing a specific immune response. In the last decade, several protocols have been developed to mature monocyte-derived DCs: each one has led to the generation of DCs showing different phenotypes and stimulatory abilities, but it is not yet known which one is the best for inducing effective immune responses. We grouped several different maturation protocols according to the downstream pathways they activated and reviewed the shared features at a transcriptomic level to reveal the potential of DCs matured by each protocol to develop Th-polarized immune responses.

Original language	English (US)
Pages (from-to)	457-466
Number of pages	10
Journal	Cancer Immunology, Immunotherapy
Volume	60
Issue number	4
DOIs	https://doi.org/10.1007/s00262-010-0954-6
State	Published - Apr 2011

Keywords

Dendritic cells
Gene profiling
Maturation
Th polarization

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00262-010-0954-6

Cite this

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title = "Monocyte-derived DC maturation strategies and related pathways: A transcriptional view",

abstract = "Ex vivo production of highly stimulator mature dendritic cells (DCs) for cellular therapy has been used to treat different pathological conditions with the aim of inducing a specific immune response. In the last decade, several protocols have been developed to mature monocyte-derived DCs: each one has led to the generation of DCs showing different phenotypes and stimulatory abilities, but it is not yet known which one is the best for inducing effective immune responses. We grouped several different maturation protocols according to the downstream pathways they activated and reviewed the shared features at a transcriptomic level to reveal the potential of DCs matured by each protocol to develop Th-polarized immune responses.",

keywords = "Dendritic cells, Gene profiling, Maturation, Th polarization",

author = "Luciano Castiello and Marianna Sabatino and Ping Jin and Carol Clayberger and Marincola, {Francesco M.} and Krensky, {Alan M.} and Stroncek, {David F.}",

note = "Funding Information: Acknowledgments This work is supported by the Intramural Programs of the National Institutes of Health Clinical Center and National Cancer Institute.",

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doi = "10.1007/s00262-010-0954-6",

language = "English (US)",

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pages = "457--466",

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T1 - Monocyte-derived DC maturation strategies and related pathways

T2 - A transcriptional view

AU - Castiello, Luciano

AU - Sabatino, Marianna

AU - Jin, Ping

AU - Clayberger, Carol

AU - Marincola, Francesco M.

AU - Krensky, Alan M.

AU - Stroncek, David F.

N1 - Funding Information: Acknowledgments This work is supported by the Intramural Programs of the National Institutes of Health Clinical Center and National Cancer Institute.

PY - 2011/4

Y1 - 2011/4

N2 - Ex vivo production of highly stimulator mature dendritic cells (DCs) for cellular therapy has been used to treat different pathological conditions with the aim of inducing a specific immune response. In the last decade, several protocols have been developed to mature monocyte-derived DCs: each one has led to the generation of DCs showing different phenotypes and stimulatory abilities, but it is not yet known which one is the best for inducing effective immune responses. We grouped several different maturation protocols according to the downstream pathways they activated and reviewed the shared features at a transcriptomic level to reveal the potential of DCs matured by each protocol to develop Th-polarized immune responses.

AB - Ex vivo production of highly stimulator mature dendritic cells (DCs) for cellular therapy has been used to treat different pathological conditions with the aim of inducing a specific immune response. In the last decade, several protocols have been developed to mature monocyte-derived DCs: each one has led to the generation of DCs showing different phenotypes and stimulatory abilities, but it is not yet known which one is the best for inducing effective immune responses. We grouped several different maturation protocols according to the downstream pathways they activated and reviewed the shared features at a transcriptomic level to reveal the potential of DCs matured by each protocol to develop Th-polarized immune responses.

KW - Dendritic cells

KW - Gene profiling

KW - Maturation

KW - Th polarization

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Monocyte-derived DC maturation strategies and related pathways: A transcriptional view

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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