Monocyte haptotaxis induced by the RANTES chemokine

Christian J. Wiedermann; Elisabeth Kowald; Norbert Reinisch; Christian M. Kaehler; Irene von Luettichau; James M. Pattison; Phil Huie; Richard K. Sibley; Peter J. Nelson; Alan M. Krensky

doi:10.1016/0960-9822(93)90020-O

Monocyte haptotaxis induced by the RANTES chemokine

Christian J. Wiedermann, Elisabeth Kowald, Norbert Reinisch, Christian M. Kaehler, Irene von Luettichau, James M. Pattison, Phil Huie, Richard K. Sibley, Peter J. Nelson, Alan M. Krensky^*

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Abstract

Background: Soluble mediators and inducible cell-surface molecules coordinate the ordered cascade of events giving rise to inflammation. The specific mechanisms underlying the attraction of antigen-specific cells into a site of inflammation remain sketchy, however. In particular, it is unclear how chemoattractants cause rapidly moving immune cells to adhere to the blood vessel wall and to enter inflamed tissues. Results: Here we show that RANTES, a potent chemo-attractant for monocytes and T lymphocytes, is inducibly expressed within an inflamed organ, binds to endothelial cells, and promotes haptotaxis, the migration of cells induced by surface-bound gradients. Conclusion: These findings lead us to propose a model for the role of RANTES in the migration of antigen-specific immune cells into an inflammatory site.

Original language	English (US)
Pages (from-to)	735-739
Number of pages	5
Journal	Current Biology
Volume	3
Issue number	11
DOIs	https://doi.org/10.1016/0960-9822(93)90020-O
State	Published - Nov 1 1993

ASJC Scopus subject areas

General Agricultural and Biological Sciences
General Biochemistry, Genetics and Molecular Biology

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10.1016/0960-9822(93)90020-O

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title = "Monocyte haptotaxis induced by the RANTES chemokine",

abstract = "Background: Soluble mediators and inducible cell-surface molecules coordinate the ordered cascade of events giving rise to inflammation. The specific mechanisms underlying the attraction of antigen-specific cells into a site of inflammation remain sketchy, however. In particular, it is unclear how chemoattractants cause rapidly moving immune cells to adhere to the blood vessel wall and to enter inflamed tissues. Results: Here we show that RANTES, a potent chemo-attractant for monocytes and T lymphocytes, is inducibly expressed within an inflamed organ, binds to endothelial cells, and promotes haptotaxis, the migration of cells induced by surface-bound gradients. Conclusion: These findings lead us to propose a model for the role of RANTES in the migration of antigen-specific immune cells into an inflammatory site.",

author = "Wiedermann, {Christian J.} and Elisabeth Kowald and Norbert Reinisch and Kaehler, {Christian M.} and {von Luettichau}, Irene and Pattison, {James M.} and Phil Huie and Sibley, {Richard K.} and Nelson, {Peter J.} and Krensky, {Alan M.}",

year = "1993",

month = nov,

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doi = "10.1016/0960-9822(93)90020-O",

language = "English (US)",

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TY - JOUR

T1 - Monocyte haptotaxis induced by the RANTES chemokine

AU - Wiedermann, Christian J.

AU - Kowald, Elisabeth

AU - Reinisch, Norbert

AU - Kaehler, Christian M.

AU - von Luettichau, Irene

AU - Pattison, James M.

AU - Huie, Phil

AU - Sibley, Richard K.

AU - Nelson, Peter J.

AU - Krensky, Alan M.

PY - 1993/11/1

Y1 - 1993/11/1

N2 - Background: Soluble mediators and inducible cell-surface molecules coordinate the ordered cascade of events giving rise to inflammation. The specific mechanisms underlying the attraction of antigen-specific cells into a site of inflammation remain sketchy, however. In particular, it is unclear how chemoattractants cause rapidly moving immune cells to adhere to the blood vessel wall and to enter inflamed tissues. Results: Here we show that RANTES, a potent chemo-attractant for monocytes and T lymphocytes, is inducibly expressed within an inflamed organ, binds to endothelial cells, and promotes haptotaxis, the migration of cells induced by surface-bound gradients. Conclusion: These findings lead us to propose a model for the role of RANTES in the migration of antigen-specific immune cells into an inflammatory site.

AB - Background: Soluble mediators and inducible cell-surface molecules coordinate the ordered cascade of events giving rise to inflammation. The specific mechanisms underlying the attraction of antigen-specific cells into a site of inflammation remain sketchy, however. In particular, it is unclear how chemoattractants cause rapidly moving immune cells to adhere to the blood vessel wall and to enter inflamed tissues. Results: Here we show that RANTES, a potent chemo-attractant for monocytes and T lymphocytes, is inducibly expressed within an inflamed organ, binds to endothelial cells, and promotes haptotaxis, the migration of cells induced by surface-bound gradients. Conclusion: These findings lead us to propose a model for the role of RANTES in the migration of antigen-specific immune cells into an inflammatory site.

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Monocyte haptotaxis induced by the RANTES chemokine

Abstract

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