Monocyte haptotaxis induced by the RANTES chemokine

Christian J. Wiedermann, Elisabeth Kowald, Norbert Reinisch, Christian M. Kaehler, Irene von Luettichau, James M. Pattison, Phil Huie, Richard K. Sibley, Peter J. Nelson, Alan M. Krensky*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Background: Soluble mediators and inducible cell-surface molecules coordinate the ordered cascade of events giving rise to inflammation. The specific mechanisms underlying the attraction of antigen-specific cells into a site of inflammation remain sketchy, however. In particular, it is unclear how chemoattractants cause rapidly moving immune cells to adhere to the blood vessel wall and to enter inflamed tissues. Results: Here we show that RANTES, a potent chemo-attractant for monocytes and T lymphocytes, is inducibly expressed within an inflamed organ, binds to endothelial cells, and promotes haptotaxis, the migration of cells induced by surface-bound gradients. Conclusion: These findings lead us to propose a model for the role of RANTES in the migration of antigen-specific immune cells into an inflammatory site.

Original languageEnglish (US)
Pages (from-to)735-739
Number of pages5
JournalCurrent Biology
Volume3
Issue number11
DOIs
StatePublished - Nov 1 1993

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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