Monosomy 7 associated with pediatric acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS): Successful management by allogeneic hematopoietic stem cell transplant (HSCT)

A. D. Troubaugh-Lotrario, Morris Kletzel, R. R. Quinones, L. McGavran, M. A. Proytcheva, S. P. Hunger, J. Malcolm, D. Schissel, E. Hild, Roger H. Giller*

*Corresponding author for this work

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Pediatric acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) with monosomy 7 is associated with poor disease-free survival when treated by conventional chemotherapy, immunosuppression or supportive measures. Hematopoietic stem cell transplant (HSCT) may improve outcomes; however, data to support this are limited. To better understand the curative potential of HSCT in these patients, all cases of AML and MDS with monosomy 7 treated by two transplant programs (1992 to present) were reviewed. A total of 16 patients were treated, all by allogeneic HSCT. Primary diagnoses were MDS (N=5), therapy-related MDS (N=3), AML (N=5) and therapy-related AML (N=3). In all, 11 patients (69%) survive event-free at 2 years with median follow-up of 986 days (range 330-2011 days). Toxicity caused deaths of the five nonsurviving patients, four of whom were transplanted with active leukemia. Allogeneic HSCT is effective therapy for childhood AML and MDS associated with monosomy 7, particularly for patients with AML in complete remission and MDS.

Original languageEnglish (US)
Pages (from-to)143-149
Number of pages7
JournalBone Marrow Transplantation
Volume35
Issue number2
DOIs
StatePublished - Jan 1 2005

Keywords

  • Acute myeloid leukemia
  • Monosomy 7
  • Myelodysplastic syndrome
  • Pediatric

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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