Morbidity in children and adolescents after surgical correction of interrupted aortic arch

Michael L. O'Byrne; Laura Mercer-Rosa; Huaqing Zhao; Xuemei Zhang; Wei Yang; Ronn E. Tanel; Bradley S. Marino; Amy Cassedy; Mark A. Fogel; Jack Rychik; Stephen Paridon; Elizabeth Goldmuntz

doi:10.1007/s00246-013-0788-z

Morbidity in children and adolescents after surgical correction of interrupted aortic arch

Michael L. O'Byrne^*, Laura Mercer-Rosa, Huaqing Zhao, Xuemei Zhang, Wei Yang, Ronn E. Tanel, Bradley S. Marino, Amy Cassedy, Mark A. Fogel, Jack Rychik, Stephen Paridon, Elizabeth Goldmuntz

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Previous studies of outcome after operative correction of interrupted aortic arch (IAA) have focused on mortality and rates of reintervention. We sought to investigate the clinical status of children and adolescents after surgery for IAA. A cross-sectional study of subjects with IAA between the ages of 8 and 18 years was performed with the subjects undergoing simultaneous genetic testing, electrocardiogram, cardiac magnetic resonance imaging, cardiopulmonary exercise testing, and assessment of health status and health-related quality of life as well as concurrent retrospective cohort study reviewing their postoperative use of medical care, including operative and transcatheter reinterventions, noncardiac surgeries, and hospitalizations. Twenty-one subjects with IAA with median age of 9 years were studied. Reintervention rates were 38 % for left-ventricular outflow tract, 33 % for AA, and 24 % for both. Rates of reintervention were highest in the first year of life and decreased in subsequent years. Left-ventricular ejection fraction was preserved (72 ± 6 %). Maximal oxygen consumption, maximal work, and forced vital capacity were both significantly decreased from age and sex norms (p < 0.0001). Health status and quality of life were both severely decreased. Subjects with IAA demonstrate a significant burden of operative and transcatheter intervention and large magnitude deficits in exercise performance, health status, and health-related quality of life.

Original language	English (US)
Pages (from-to)	386-392
Number of pages	7
Journal	Pediatric cardiology
Volume	35
Issue number	3
DOIs	https://doi.org/10.1007/s00246-013-0788-z
State	Published - Mar 2014

Funding

The work in the manuscript was supported by the National Institute of Health (NIH; Grant No. HL074731) and National Center for Research Resources (Grant No. UL1RR024134). M. L. O’Byrne is supported by the NIH (Grant No. T32 HL007915). The content is solely the responsibility of the authors and does not necessarily represent the official view of the National Center for Research Resources or the NIH. The Heart Institute Research Core at Cincinnati Children’s Hospital Medical Center assisted with quality-of-life scoring and analysis. Otherwise, the authors are solely responsible for the design and conduct of this study and its analyses, the drafting and editing of this manuscript, and its final contents. The authors acknowledge Sharon Edman, who acted as a database manager for this project.

Keywords

Cardiac MRI
Cardiopulmonary exercise testing
Congenital heart disease
Quality of life

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00246-013-0788-z

Cite this

@article{4a5ba88573e042fb812b1aa554060628,

title = "Morbidity in children and adolescents after surgical correction of interrupted aortic arch",

abstract = "Previous studies of outcome after operative correction of interrupted aortic arch (IAA) have focused on mortality and rates of reintervention. We sought to investigate the clinical status of children and adolescents after surgery for IAA. A cross-sectional study of subjects with IAA between the ages of 8 and 18 years was performed with the subjects undergoing simultaneous genetic testing, electrocardiogram, cardiac magnetic resonance imaging, cardiopulmonary exercise testing, and assessment of health status and health-related quality of life as well as concurrent retrospective cohort study reviewing their postoperative use of medical care, including operative and transcatheter reinterventions, noncardiac surgeries, and hospitalizations. Twenty-one subjects with IAA with median age of 9 years were studied. Reintervention rates were 38 % for left-ventricular outflow tract, 33 % for AA, and 24 % for both. Rates of reintervention were highest in the first year of life and decreased in subsequent years. Left-ventricular ejection fraction was preserved (72 ± 6 %). Maximal oxygen consumption, maximal work, and forced vital capacity were both significantly decreased from age and sex norms (p < 0.0001). Health status and quality of life were both severely decreased. Subjects with IAA demonstrate a significant burden of operative and transcatheter intervention and large magnitude deficits in exercise performance, health status, and health-related quality of life.",

keywords = "Cardiac MRI, Cardiopulmonary exercise testing, Congenital heart disease, Quality of life",

author = "O'Byrne, {Michael L.} and Laura Mercer-Rosa and Huaqing Zhao and Xuemei Zhang and Wei Yang and Tanel, {Ronn E.} and Marino, {Bradley S.} and Amy Cassedy and Fogel, {Mark A.} and Jack Rychik and Stephen Paridon and Elizabeth Goldmuntz",

note = "Funding Information: The work in the manuscript was supported by the National Institute of Health (NIH; Grant No. HL074731) and National Center for Research Resources (Grant No. UL1RR024134). M. L. O{\textquoteright}Byrne is supported by the NIH (Grant No. T32 HL007915). The content is solely the responsibility of the authors and does not necessarily represent the official view of the National Center for Research Resources or the NIH. The Heart Institute Research Core at Cincinnati Children{\textquoteright}s Hospital Medical Center assisted with quality-of-life scoring and analysis. Otherwise, the authors are solely responsible for the design and conduct of this study and its analyses, the drafting and editing of this manuscript, and its final contents. The authors acknowledge Sharon Edman, who acted as a database manager for this project. ",

year = "2014",

month = mar,

doi = "10.1007/s00246-013-0788-z",

language = "English (US)",

volume = "35",

pages = "386--392",

journal = "Pediatric cardiology",

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T1 - Morbidity in children and adolescents after surgical correction of interrupted aortic arch

AU - O'Byrne, Michael L.

AU - Mercer-Rosa, Laura

AU - Zhao, Huaqing

AU - Zhang, Xuemei

AU - Yang, Wei

AU - Tanel, Ronn E.

AU - Marino, Bradley S.

AU - Cassedy, Amy

AU - Fogel, Mark A.

AU - Rychik, Jack

AU - Paridon, Stephen

AU - Goldmuntz, Elizabeth

N1 - Funding Information: The work in the manuscript was supported by the National Institute of Health (NIH; Grant No. HL074731) and National Center for Research Resources (Grant No. UL1RR024134). M. L. O’Byrne is supported by the NIH (Grant No. T32 HL007915). The content is solely the responsibility of the authors and does not necessarily represent the official view of the National Center for Research Resources or the NIH. The Heart Institute Research Core at Cincinnati Children’s Hospital Medical Center assisted with quality-of-life scoring and analysis. Otherwise, the authors are solely responsible for the design and conduct of this study and its analyses, the drafting and editing of this manuscript, and its final contents. The authors acknowledge Sharon Edman, who acted as a database manager for this project.

PY - 2014/3

Y1 - 2014/3

N2 - Previous studies of outcome after operative correction of interrupted aortic arch (IAA) have focused on mortality and rates of reintervention. We sought to investigate the clinical status of children and adolescents after surgery for IAA. A cross-sectional study of subjects with IAA between the ages of 8 and 18 years was performed with the subjects undergoing simultaneous genetic testing, electrocardiogram, cardiac magnetic resonance imaging, cardiopulmonary exercise testing, and assessment of health status and health-related quality of life as well as concurrent retrospective cohort study reviewing their postoperative use of medical care, including operative and transcatheter reinterventions, noncardiac surgeries, and hospitalizations. Twenty-one subjects with IAA with median age of 9 years were studied. Reintervention rates were 38 % for left-ventricular outflow tract, 33 % for AA, and 24 % for both. Rates of reintervention were highest in the first year of life and decreased in subsequent years. Left-ventricular ejection fraction was preserved (72 ± 6 %). Maximal oxygen consumption, maximal work, and forced vital capacity were both significantly decreased from age and sex norms (p < 0.0001). Health status and quality of life were both severely decreased. Subjects with IAA demonstrate a significant burden of operative and transcatheter intervention and large magnitude deficits in exercise performance, health status, and health-related quality of life.

AB - Previous studies of outcome after operative correction of interrupted aortic arch (IAA) have focused on mortality and rates of reintervention. We sought to investigate the clinical status of children and adolescents after surgery for IAA. A cross-sectional study of subjects with IAA between the ages of 8 and 18 years was performed with the subjects undergoing simultaneous genetic testing, electrocardiogram, cardiac magnetic resonance imaging, cardiopulmonary exercise testing, and assessment of health status and health-related quality of life as well as concurrent retrospective cohort study reviewing their postoperative use of medical care, including operative and transcatheter reinterventions, noncardiac surgeries, and hospitalizations. Twenty-one subjects with IAA with median age of 9 years were studied. Reintervention rates were 38 % for left-ventricular outflow tract, 33 % for AA, and 24 % for both. Rates of reintervention were highest in the first year of life and decreased in subsequent years. Left-ventricular ejection fraction was preserved (72 ± 6 %). Maximal oxygen consumption, maximal work, and forced vital capacity were both significantly decreased from age and sex norms (p < 0.0001). Health status and quality of life were both severely decreased. Subjects with IAA demonstrate a significant burden of operative and transcatheter intervention and large magnitude deficits in exercise performance, health status, and health-related quality of life.

KW - Cardiac MRI

KW - Cardiopulmonary exercise testing

KW - Congenital heart disease

KW - Quality of life

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JF - Pediatric cardiology

IS - 3

ER -

Morbidity in children and adolescents after surgical correction of interrupted aortic arch

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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