More complex transcriptional regulation and stress response by MOF

N. Horikoshi, C. R. Hunt, T. K. Pandita*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

MOF (males absent on the first) was initially discovered as a dosage compensation factor that regulates the epigenetic acetylation of histone H4 lysine 16. In this issue, Sheikh et al. demonstrate that MOF expression is not required for normal kidney tissue function but is required for maintaining transcriptional regulation under conditions of stress. This work along with results from previous investigators highlights the importance of the cell lineage-chromatin modification interaction in determining transcriptional programs and physiological outcomes under normal and stress conditions.

Original languageEnglish (US)
Pages (from-to)2681-2683
Number of pages3
JournalOncogene
Volume35
Issue number21
DOIs
StatePublished - May 1 2016

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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