An unresolved question in vasculogenesis is how mammalian endothelial cells make lumens in developing vessels. In this issue of Developmental Cell, Strilic et al. present a comprehensive analysis of murine arterial lumen formation that defines cellular and molecular events required for lumen morphogenesis and argues against a previous paradigm of lumen formation.
ASJC Scopus subject areas
- Molecular Biology
- Biochemistry, Genetics and Molecular Biology(all)
- Developmental Biology
- Cell Biology