TY - JOUR
T1 - More Than Bricks and Mortar
T2 - Comments on Protein and Amino Acid Metabolism in the Heart
AU - Taegtmeyer, Heinrich
AU - Harinstein, Matthew E.
AU - Gheorghiade, Mihai
N1 - Funding Information:
Work in the authors' laboratories was supported by the National Heart, Lung, and Blood Institute, US Public Health Service, National Institutes of Health (NHLBI/USPHS/NIH).
PY - 2008/6/2
Y1 - 2008/6/2
N2 - Few cardiologists have considered that constituents of the heart muscle cells are in a continuous state of flux. The proteins of sarcomeres, mitochondria, membranes, the cytosol, and even ribosomes and the cell nucleus, are continuously degraded and remade. Schoenheimer's concept of the "dynamic state of body constituents," has received relatively little attention in the world of cardiovascular research, at least not until recently. We propose that the term nutrition of the heart extends well beyond the supply of energy-providing substrates and includes the supply of amino acids, micronutrients, and regulators of protein synthesis and degradation. This short article is written to make the reader think in broad concepts.
AB - Few cardiologists have considered that constituents of the heart muscle cells are in a continuous state of flux. The proteins of sarcomeres, mitochondria, membranes, the cytosol, and even ribosomes and the cell nucleus, are continuously degraded and remade. Schoenheimer's concept of the "dynamic state of body constituents," has received relatively little attention in the world of cardiovascular research, at least not until recently. We propose that the term nutrition of the heart extends well beyond the supply of energy-providing substrates and includes the supply of amino acids, micronutrients, and regulators of protein synthesis and degradation. This short article is written to make the reader think in broad concepts.
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U2 - 10.1016/j.amjcard.2008.02.064
DO - 10.1016/j.amjcard.2008.02.064
M3 - Article
C2 - 18514624
AN - SCOPUS:44449104602
VL - 101
SP - S3-S7
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 11 SUPPL.
ER -