Morphological characterization of cellular and extracellular components of 7,12 dimethylbenz[a]anthracene induced melanoma tumours.

B. Persky*, C. C. Huerta, M. J. Hendrix

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Subcutaneous tumours were induced in castrated golden Syrian hamsters by 7,12 dimethylbenz[a]anthracene (DMBA), an agent known to produce papillomas and carcinomas. The morphological characteristics of the cellular and extracellular constituents of the chemically-induced tumours were indicative of melanoma. Tumours were induced by three injections of DMBA into the jugular vein over a 3 month period. Dermal tumour development within the dorsal integument and groin region ultimately projected into the epidermis and occurred during the 3 month period subsequent to the last DMBA injection. Suspect melanoma tumours were excised and processed for light microscopic (LM) and transmission electron microscopic (TEM) studies. Histochemical staining methods facilitated the characterization of the differentiated tumour components in this hamster melanoma model. The model presented could allow observations from initial melanoma transformation events through advanced stages of metastasis within a window of 7 months.

Original languageEnglish (US)
Pages (from-to)493-499
Number of pages7
JournalBritish journal of experimental pathology
Volume68
Issue number4
StatePublished - Aug 1987

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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