Morphological effects of Compound 48/80, polymyxin B sulfate, and dextran on rat skeletal muscle

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2 Scopus citations

Abstract

A single intraperitoneal dose of the rat mast cell disrupters, polymyxin B sulfate or Compound 48/80, produced necrosis of O% to 5% of the skeletal muscle fibers in biopsy specimens of the rat vastus lateralis muscle. Dextran, which is also a rat mast cell disrupter, generally did not produce necrosis. Single doses of polymyxin B sulfate, Compound 48/80, and dextran produced myofibrillar disruption or Z band streaming in 15% to 26% of nonnecrotic fibers in the vastus lateralis muscle specimens. The association of these pathologic characteristics with mitochondrial injury and the relation of these types of pathologic changes to changes produced by these drugs in plasma creatine phosphokinase activity is discussed.

Original languageEnglish (US)
Pages (from-to)118-123
Number of pages6
JournalArchives of Pathology and Laboratory Medicine
Volume96
Issue number2
StatePublished - Dec 1 1973

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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