Morphology of a naphthalene induced bronchiolar lesion

D. Mahvi, H. Bank, R. Harley

Research output: Contribution to journalArticlepeer-review

113 Scopus citations


Nonciliated bronchiolar epithelial (Clara) cells are selectively damaged by intraperitoneal administration of naphthalene. These changes were examined using light microscopy, transmission electron microscopy, and scanning electron microscopy. Naphthalene administration causes the Clara cells to expand and exfoliate shortly thereafter. Following exfoliation the remaining ciliated cells show morphologic abnormalities, including cilia loss and ballooning of remaining cilia. Upon regeneration of the Clara cells the ciliated cells gradually return to their normal appearance. One possible explanation for these findings is that the Clara cell secretions affect the physiologic state of the surrounding ciliated cells.

Original languageEnglish (US)
Pages (from-to)559-572
Number of pages14
JournalAmerican Journal of Pathology
Issue number3
StatePublished - Jan 1 1977

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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