Abstract
The morphology of lymphocytes in blood and bone marrow from patients with chronic lymphocytic leukemia was studied; blood lymphocyte morphology was related to survival. Three primary morphologic groups emerged. Group I was characterized by small to medium-sized lymphocytes with narrow rims of cytoplasm and coarsely clumped nuclear chromatin. In group II the predominant lymphocytes were large with abundant cytoplasm. Group III was characterized by a heterogeneous population of lymphocytes with characteristics of both groups I and II. Clinical features of the patients were studied, and B and T typing of the lymphocytes was done. The median survival in group I was 26+ months; In group II 46+ months; and in group III 50+ months. Our data are at variance with previous reports and suggest that survival in patients with large lymphocytes Is longer than in those with small lymphocytes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 316-324 |
| Number of pages | 9 |
| Journal | The American journal of medicine |
| Volume | 59 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 1975 |
Funding
LoANN C. PETERSON, M.D. CLARA D. BLOOMFIELD, M.D. R. DOROTHY SUNDSERG, Ph.D., M.D. K. J. GAJL-PECZALSKA,M .D. RiCHARD D. SRUNNING, M.D. M&meapoiisM, innesofa From tha Department of Laboratory Medicine and Pathology.a nd Section of Medical Oncob gy. University of Minnesota Health Sciences Center, Minneapoiis, Minnesota 55455. This study was supportedi n part by Grant CA 08832 from the National Dancer institute of the US. Public Health Service, the Leukemia Research Fund. inc., and the American Cancer Society. Requests for reprints shcuid be addressed to Dr. Richard D. Brunning.B ox 198. Unhmsity of Minnesote Hospltei, Minneapob. Minnesota 55455. Manuscdpt accepted February 28, 1975.
ASJC Scopus subject areas
- General Medicine
