Morphology of chronic lymphocytic leukemia and its relationship to survival

LoAnn C. Peterson, Clara D. Bloomfield, R. Dorothy Sundberg, K. J. Gajl-Peczalska, Richard D. Brunning*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


The morphology of lymphocytes in blood and bone marrow from patients with chronic lymphocytic leukemia was studied; blood lymphocyte morphology was related to survival. Three primary morphologic groups emerged. Group I was characterized by small to medium-sized lymphocytes with narrow rims of cytoplasm and coarsely clumped nuclear chromatin. In group II the predominant lymphocytes were large with abundant cytoplasm. Group III was characterized by a heterogeneous population of lymphocytes with characteristics of both groups I and II. Clinical features of the patients were studied, and B and T typing of the lymphocytes was done. The median survival in group I was 26+ months; In group II 46+ months; and in group III 50+ months. Our data are at variance with previous reports and suggest that survival in patients with large lymphocytes Is longer than in those with small lymphocytes.

Original languageEnglish (US)
Pages (from-to)316-324
Number of pages9
JournalThe American journal of medicine
Issue number3
StatePublished - Sep 1975

ASJC Scopus subject areas

  • Medicine(all)

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