Morphometric analysis of pediatric and nonhyperplastic prostate glands: Evidence that BPH is not a unique stromal process

Ellen Shapiro*, Victor Hartanto, Elizabeth J. Perlman, Rui Tang, Bo Wang, Herbert Lepor

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

BACKGROUND. Although quantitative morphometry of benign prostatic hyperplasia (BPH) has been described, there is a paucity of information on the morphometry of the nonhyperplastic prostate. This study determines the histologic composition of prostates obtained from males, ages 2 days to 40 years, in order to provide insights into the morphometry of the 'normal' gland. METHODS. The histologic composition of 45 prostates was obtained from autopsies of males with age groups stratified to reflect the neonatal childhood, peripubertal, adolescent, and young adult periods. Double immunoenzymatic staining and computer image analysis were used to determine the mean area densities of the smooth muscle (SM), connective tissue (CT), glandular epithelium (E), and lumen (L). RESULTS. A progressive decrease in SM area density throughout childhood, prepuberty, and puberty was seen. The density of SM significantly increased following puberty and throughout adolescence and early adulthood. There was a concomitant increase in CT from the neonatal period throughout childhood, prepuberty, and puberty, and a decrease after puberty and throughout adolescence and early adulthood. Since the changes in SM and CT were inversely related, the percent contribution of the stromal compartment to the total gland remained constant. CONCLUSIONS. The stromal to epithelial ratio remains constant from birth to age 40 in nonhyperplastic glands and is similar to the ratios in asymptomatic and symptomatic BPH tissues.

Original languageEnglish (US)
Pages (from-to)177-182
Number of pages6
JournalProstate
Volume33
Issue number3
DOIs
StatePublished - Nov 1 1997

Keywords

  • Histology
  • Prostate
  • Quantitative morphometry
  • Smooth muscle

ASJC Scopus subject areas

  • Oncology
  • Urology

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