Morphometric and Histologic Substrates of Cingulate Integrity in Elders with Exceptional Memory Capacity

Tamar Gefen, Melanie Peterson, Steven T. Papastefan, Adam Martersteck, Kristen Whitney, Alfred Rademaker, Eileen H. Bigio, Sandra Weintraub, Emily Rogalski, M. Marsel Mesulam, Changiz Geula

Research output: Contribution to journalArticlepeer-review

84 Scopus citations


This human study is based on an established cohort of “SuperAgers,” 80_-year-old individuals with episodic memory function at a level equal to, or better than, individuals 20 –30 years younger.Apreliminary investigation using structural brain imaging revealed a region of anterior cingulate cortex that was thicker in SuperAgers compared with healthy 50- to 65-year-olds. Here, we investigated the in vivo structural features of cingulate cortex in a larger sample of SuperAgers and conducted a histologic analysis of this region in postmortem specimens. A region-of-interest MRI structural analysis found cingulate cortex to be thinner in cognitively average 80_year olds (n_ 21) than in the healthy middle-aged group (n_18). A region of the anterior cingulate cortex in the right hemisphere displayed greater thickness in SuperAgers (n_31) compared with cognitively average 80_year olds and also to themuchyounger healthy 50–60 year olds (p _ 0.01). Postmortem investigations were conducted in the cingulate cortex in five SuperAgers, five cognitively average elderly individuals, and five individuals with amnestic mild cognitive impairment. Compared with other subject groups, SuperAgers showed a lower frequency of Alzheimer-type neurofibrillary tangles (p_0.05). There were no differences in total neuronal size or count between subject groups. Interestingly, relative to total neuronal packing density, there was a higher density of von Economo neurons (p_0.05), particularly in anterior cingulate regions of SuperAgers.

Original languageEnglish (US)
Pages (from-to)1781-1791
Number of pages11
JournalJournal of Neuroscience
Issue number4
StatePublished - Jan 28 2015


  • Aging
  • Alzheimer’s pathology
  • Cingulate cortex
  • Cistology
  • Cognition
  • Structural MRI

ASJC Scopus subject areas

  • Neuroscience(all)


Dive into the research topics of 'Morphometric and Histologic Substrates of Cingulate Integrity in Elders with Exceptional Memory Capacity'. Together they form a unique fingerprint.

Cite this