Morphometric model of normal rabbit dorsal root ganglia

Robert F. McLain*, James Neil Weinstein

*Corresponding author for this work

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The rebbit dorsal root ganglion Is an Important model of pain mechanisms In lha human spina. A morphometric model of tti-e normal rabbit dorsal root gansilDn was constructed to provide quantitative comparisons with Injured ganglia. Lumber ganglia were studied under light and electron microscopy using simple stereologic methods, Neuronal diameter rangRd from 18 to 05 ^.m, with 60% between 30 and 50 ^.m. Neurons constituted approximately 30% of dorsal root ganglion volume, and neuronal nuclei accounted for 14% of neuronal volums and 4% of dorsal root ganglion volume. Contributions from organellas to dorsal root ganglion volume were: mitochondria, 1, 6%; rough endoplasmic reticulum, 9.4%; lysosomes, 0.2%; gelgr, 0.5%. This morphomotric modal facilitates quantitative analysis of ganglia exposed to direct or Indirect stimuli, providing Important information on the structural changes that influence pain oroductiom.

Original languageEnglish (US)
Pages (from-to)1746-1752
Number of pages7
JournalSpine
Volume18
Issue number13
DOIs
StatePublished - Oct 1993

Keywords

  • Dorsal root ganglion
  • Low-back pain
  • Rabbit
  • Stereology

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Clinical Neurology

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