Mortality of bullous pemphigoid: An evaluation of 223 patients and comparison with the mortality in the general population in the United States

Sareeta R.S. Parker*, Senait Dyson, Stacey Brisman, Michelle Pennie, Robert A. Swerlick, Rizwana Khan, Sue Manos, Benjamin D. Korman, Zongqi Xia, Neil J. Korman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

Background: There are large discrepancies in reported mortality for bullous pemphigoid (BP). Objective: We sought to determine the mortality of a large cohort of patients with BP and compare this with age-matched control subjects. Methods: Data were collected on 223 patients with a new diagnosis of BP between 1998 and 2003 through our cutaneous immunofluorescence laboratory databases. The mortality of patients with BP was compared with that of age-matched control subjects in the general US population. Results: The 1-, 2-, and 5-year mortality was 0.23 (95% confidence interval = 0.18, 0.29), 0.37 (95% confidence interval = 0.31, 0.44), and 0.50 (95% confidence interval = 0.42, 0.57), respectively. However, relative to age-matched control subjects, no difference in expected mortality was detected. Limitations: This was a retrospective cohort analysis. Conclusions: Mortality of patients with BP is more likely related to advanced age and associated medical conditions than to disease-specific factors.

Original languageEnglish (US)
Pages (from-to)582-588
Number of pages7
JournalJournal of the American Academy of Dermatology
Volume59
Issue number4
DOIs
StatePublished - Oct 1 2008

ASJC Scopus subject areas

  • Dermatology

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