Mortality outcomes and 30-day readmissions associated with coronary artery aneurysms; a National Database Study

Tanveer Mir*, Mohammed Uddin, Khalid Changal, Waqas Qureshi, Jarrett Weinberger, Javed Wani, Kameswari Maganti, Tanveer Rab, Ehab Eltahawy, Mujeeb Sheikh

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The literature on prevalence and outcomes of coronary artery aneurysm (CAA) in the United States (US) is limited. Objective: To study the prevalence, outcomes, and trends of CAA. Methods: Data from the national readmissions database (NRD) sample that constitutes 49.1% of the stratified sample of all hospitals in the US were analyzed for CAA among coronary angiography (CA) related hospitalizations for the years 2012–2018. Results: A total of 6,843,910 index CA related hospitalizations were recorded for the years 2012–2018 in the NRD (Mean age 64.37 ± 13.30 years' 38.6% females). Of these 9671 (0.141%) were CAA, 5092 (52.7%) without-ACS and 4579 (47.3%) with ACS [NSTEMI occurred in 2907(63.5%) and STEMI in 1672(36.5%)]. In-hospital mortality among CAA was comparable to those without-CAA on angiography (n-209,2.17% vs n = 175,120,2.56%;p = 0.08). CAA patients who presented with ACS vs those without ACS had higher mortality (n = 150,3.28%vsn = 60,1.16%;p < 0.001) cardiogenic shock 6.9%vs2%, ventricular arrythmias 9.2%vs5.2%, coronary dissection 58%vs42.7%, and need for mechanical circulatory support 7%vs2.7% respectively. Percutaneous coronary intervention (PCI) was performed among 45.2% patients; however, on coarsened exact matching of baseline characteristics, PCI had no association with mortality, patients (OR 1.22, 95%CI0.69–2.16, p = 0.49). The prevalence of CAA on CA trend towards increased mortality with ACS increased over the years 2012–2018 (linear p-trend <0.05). The 30-day readmissions rate were 13.8% (non-CAA) vs 4.6% (CAA) p = 0.001 predominantly cardiovascular causes (50.9%vs70.7%) and PCI on readmission (7.06%vs17.5%). Conclusion: CAA is an uncommon anomaly noted on coronary angiography. The higher mortality in patients with ACS and increasing trend of CAA-ACS warrants more research.

Original languageEnglish (US)
Pages (from-to)6-11
Number of pages6
JournalInternational Journal of Cardiology
Volume356
DOIs
StatePublished - Jun 1 2022

Keywords

  • Coronary angiography
  • Coronary artery aneurysm
  • Coronary artery dissection
  • Coronary ectasia
  • PCI
  • Prevalence

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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