TY - JOUR
T1 - Mortality, rehospitalization, and post-transplant complications in gender-mismatched heart transplant recipients
AU - Jalowiec, Anne
AU - Grady, Kathleen L.
AU - White-Williams, Connie
N1 - Funding Information:
Funding: National Institutes of Health (NINR: #NR01693, #NR01693/S, #5R01-NR01693; NHLBI: #HL49336), Sandoz Pharmaceuticals Corporation, Earl Bane Estate, American Association of Critical-Care Nurses, Sigma Theta Tau, Loyola University Research Committee, Loyola University School of Nursing, Loyola University Medical Center. Study PI: Dr Anne Jalowiec.
Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017/7
Y1 - 2017/7
N2 - Background Limited research has been published on outcomes in heart transplant (HT) recipients with gender-mismatched donors. Objective Compare 3-year post-transplant outcomes in 2 groups of gender-mismatched HT recipients and a no-mismatch group. Methods Sample: 347 HT recipients: 21.3% (74) received a heart from the opposite gender: Group 1: same gender donor/recipient (273, 78.7%); Group 2: female donor/male recipient (40, 11.5%); Group 3: male donor/female recipient (34, 9.8%). Outcomes: mortality, hospitalization, and complications. Results Female patients with male heart donors had shorter 3-year survival, were rehospitalized more days after HT discharge, and had more treated acute rejection episodes and cardiac allograft vasculopathy. No differences were found in: HT length of stay, respiratory failure, stroke, cancer, renal dysfunction, steroid-induced diabetes, number of IV-treated infections, or the timing of infection and rejection. Conclusion Female HT recipients with male donors had worse 3-year outcomes as compared to male-mismatch and no-mismatch groups.
AB - Background Limited research has been published on outcomes in heart transplant (HT) recipients with gender-mismatched donors. Objective Compare 3-year post-transplant outcomes in 2 groups of gender-mismatched HT recipients and a no-mismatch group. Methods Sample: 347 HT recipients: 21.3% (74) received a heart from the opposite gender: Group 1: same gender donor/recipient (273, 78.7%); Group 2: female donor/male recipient (40, 11.5%); Group 3: male donor/female recipient (34, 9.8%). Outcomes: mortality, hospitalization, and complications. Results Female patients with male heart donors had shorter 3-year survival, were rehospitalized more days after HT discharge, and had more treated acute rejection episodes and cardiac allograft vasculopathy. No differences were found in: HT length of stay, respiratory failure, stroke, cancer, renal dysfunction, steroid-induced diabetes, number of IV-treated infections, or the timing of infection and rejection. Conclusion Female HT recipients with male donors had worse 3-year outcomes as compared to male-mismatch and no-mismatch groups.
KW - Female-mismatched cardiac allograft vasculopathy
KW - Female-mismatched heart transplant outcomes
KW - Female-mismatched heart transplant rehospitalization
KW - Female-mismatched heart transplant rejection
KW - Female-mismatched heart transplant survival
KW - Heart transplant gender-mismatch
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U2 - 10.1016/j.hrtlng.2017.04.004
DO - 10.1016/j.hrtlng.2017.04.004
M3 - Article
C2 - 28501318
AN - SCOPUS:85019069417
SN - 0147-9563
VL - 46
SP - 265
EP - 272
JO - Heart and Lung: Journal of Acute and Critical Care
JF - Heart and Lung: Journal of Acute and Critical Care
IS - 4
ER -
