Mortality, rehospitalization, and post-transplant complications in gender-mismatched heart transplant recipients

Anne Jalowiec*, Kathleen L Grady, Connie White-Williams

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Background Limited research has been published on outcomes in heart transplant (HT) recipients with gender-mismatched donors. Objective Compare 3-year post-transplant outcomes in 2 groups of gender-mismatched HT recipients and a no-mismatch group. Methods Sample: 347 HT recipients: 21.3% (74) received a heart from the opposite gender: Group 1: same gender donor/recipient (273, 78.7%); Group 2: female donor/male recipient (40, 11.5%); Group 3: male donor/female recipient (34, 9.8%). Outcomes: mortality, hospitalization, and complications. Results Female patients with male heart donors had shorter 3-year survival, were rehospitalized more days after HT discharge, and had more treated acute rejection episodes and cardiac allograft vasculopathy. No differences were found in: HT length of stay, respiratory failure, stroke, cancer, renal dysfunction, steroid-induced diabetes, number of IV-treated infections, or the timing of infection and rejection. Conclusion Female HT recipients with male donors had worse 3-year outcomes as compared to male-mismatch and no-mismatch groups.

Original languageEnglish (US)
Pages (from-to)265-272
Number of pages8
JournalHeart and Lung: Journal of Acute and Critical Care
Volume46
Issue number4
DOIs
StatePublished - Jul 1 2017

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Keywords

  • Female-mismatched cardiac allograft vasculopathy
  • Female-mismatched heart transplant outcomes
  • Female-mismatched heart transplant rehospitalization
  • Female-mismatched heart transplant rejection
  • Female-mismatched heart transplant survival
  • Heart transplant gender-mismatch

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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