Mosaic Interdigitated Structure in Nanoparticle-Templated Phospholipid Bilayer Supports Partial Lipidation of Apolipoprotein A-I

Wangqiang Sun*, Weiqiang Wu, Kaylin M. McMahon, Jonathan S. Rink, C. Shad Thaxton

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

A study is conducted to demonstrate that mosaic interdigitated structure in nanoparticle-templated phospholipid bilayer supports partial lipidation of apolipoprotein A-I. Phospholipid bilayers provide critical platforms for studying proteins. On the other hand, hybrid conjugates that combine phospholipid bilayers with nanostructures often exhibit new properties. There is a strong synergy between nanoparticles and bound phospholipids, which may impact the phase structure of nanoparticle-templated phospholipids and induce new conformations and functions of lapidated proteins.

Original languageEnglish (US)
Pages (from-to)300-305
Number of pages6
JournalParticle and Particle Systems Characterization
Volume33
Issue number6
DOIs
StatePublished - Jun 1 2016

Keywords

  • apolipoprotein A-I
  • bionanostructure
  • high-density lipoprotein
  • lipidation
  • phospholipid

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

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