Moses Laser Enucleation of the Prostate (MoLEP): Use of Pulse Modulated Holmium Laser Technology for Prostate Enucleation

Mark Alexander Assmus*, Amy E. Krambeck

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Purpose of Review: In this review, the current literature available that evaluates the use of Moses pulse-modulated holmium technology for laser enucleation of the prostate will be addressed. Topics include safety and surgical case efficiency, length of post-operative foley catheter and hospital stay, surgical outcomes, and areas of future research. Recent Findings: Some early retrospective studies and select randomized control trials seek to determine if novel laser technologies can improve peri-operative outcome measures or reduce the morbidity of endoscopic enucleation of the prostate while maintaining or improving the safety profile of holmium laser enucleation of the prostate (HoLEP). Both objective and subjective outcomes of HoLEP are seen to be preserved in patients undergoing Moses laser enucleation of the prostate (MoLEP), with recent studies highlighting high rates of successful same-day catheter removal and same-day discharge in an increasingly wide range of patients. Summary: Initial studies focusing on Moses laser technology for prostate enucleation are promising. Further high-quality randomized controlled trials evaluating MoLEP are required to clarify the clinical impact of this laser technology on prostate enucleation outcomes as well as comparing to alternative novel benign prostate hyperplasia (BPH) treatments.

Original languageEnglish (US)
Pages (from-to)165-172
Number of pages8
JournalCurrent Bladder Dysfunction Reports
Issue number2
StatePublished - Jun 2023


  • HoLEP
  • Laser technology
  • Moses
  • Pulse modulated

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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