MOSFET-embedded microcantilevers: An all-electronic label- And optics-free signal transduction paradigm for bio-chem sensing

Gajendra S Shekhawat*, Soo Hyun Tark, Vinayak P Dravid

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We recently introduced all-electronic label- and optics-free detection paradigm for biochemical binding events on metal-oxide semiconductor field-effect transistor (MOSFET)-embedded microcantilevers. Microcantilever bending as small as ∼5nm, leads to a measurable and reproducible change in the MOSFET drain current, which forms the basis for the microelectronics-based detection of molecular binding events. MOSFET-embedded microcantilevers are able to detect diverse probe-target binding events, ranging from DNA hybridization to protein-protein binding, at high sensitivity. Such label- and optics-free all-electronic MOSFET detection approach will bridge the current gap between integration of nano-bio nanostructures with microelectronics, and promises a universal and widely deployable bio-chem diagnosis platform, compatible with all the advantages of established CMOS technology for wide variety of biomolecular and chemical detection and diagnosis.

Original languageEnglish (US)
Title of host publication2006 5th IEEE Conference on Sensors
Pages746-748
Number of pages3
DOIs
StatePublished - Dec 1 2006
Event2006 5th IEEE Conference on Sensors - Daegu, Korea, Republic of
Duration: Oct 22 2006Oct 25 2006

Other

Other2006 5th IEEE Conference on Sensors
CountryKorea, Republic of
CityDaegu
Period10/22/0610/25/06

ASJC Scopus subject areas

  • Engineering (miscellaneous)
  • Electrical and Electronic Engineering

Fingerprint Dive into the research topics of 'MOSFET-embedded microcantilevers: An all-electronic label- And optics-free signal transduction paradigm for bio-chem sensing'. Together they form a unique fingerprint.

  • Cite this