Mossy fiber LTP: A presynaptic cAMP-dependent form of plasticity

Herman B. Fernandes, Anis Contractor

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Mossy fiber synapses in the hippocampus are formed by the axons of the granule cells and their postsynaptic targets in the hilar and CA3 regions of the hippocampus. The excitatory synapses formed with the principal pyramidal neurons exhibit a number of unique structural and functional properties, including a distinctive form of long-term potentiation (LTP) that is expressed in the presynaptic terminal and is dependent on cyclic AMP (cAMP) signaling. Here we review the current state of our understanding of this form of synaptic plasticity.

Original languageEnglish (US)
Title of host publicationThe Curated Reference Collection in Neuroscience and Biobehavioral Psychology
PublisherElsevier Science Ltd.
Pages551-554
Number of pages4
ISBN (Electronic)9780128093245
DOIs
StatePublished - Jan 1 2016

Keywords

  • Adenylyl cyclase
  • cAMP
  • Epac2
  • Hippocampus
  • LTP
  • Mossy fiber
  • Munc13-1
  • PKA
  • Presynaptic
  • Rab3a
  • RIM1α
  • Syt12

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Fernandes, H. B., & Contractor, A. (2016). Mossy fiber LTP: A presynaptic cAMP-dependent form of plasticity. In The Curated Reference Collection in Neuroscience and Biobehavioral Psychology (pp. 551-554). Elsevier Science Ltd.. https://doi.org/10.1016/B978-0-12-809324-5.02780-2