Mossy fiber LTP: A presynaptic cAMP-dependent form of plasticity

Herman B. Fernandes, Anis Contractor

Research output: Chapter in Book/Report/Conference proceedingChapter


Mossy fiber synapses in the hippocampus are formed by the axons of the granule cells and their postsynaptic targets in the hilar and CA3 regions of the hippocampus. The excitatory synapses formed with the principal pyramidal neurons exhibit a number of unique structural and functional properties, including a distinctive form of long-term potentiation (LTP) that is expressed in the presynaptic terminal and is dependent on cyclic AMP (cAMP) signaling. Here we review the current state of our understanding of this form of synaptic plasticity.

Original languageEnglish (US)
Title of host publicationThe Curated Reference Collection in Neuroscience and Biobehavioral Psychology
PublisherElsevier Science Ltd.
Number of pages4
ISBN (Electronic)9780128093245
StatePublished - Jan 1 2016


  • Adenylyl cyclase
  • Epac2
  • Hippocampus
  • LTP
  • Mossy fiber
  • Munc13-1
  • PKA
  • Presynaptic
  • RIM1α
  • Rab3a
  • Syt12
  • cAMP

ASJC Scopus subject areas

  • General Medicine


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