Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia

K. J. Hatanpaa; D. M. Blass; O. Pletnikova; B. J. Crain; E. H. Bigio; J. C. Hedreen; C. L. White; J. C. Troncoso

doi:10.1212/01.WNL.0000129543.46734.C0

Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia

K. J. Hatanpaa^*, D. M. Blass, O. Pletnikova, B. J. Crain, E. H. Bigio, J. C. Hedreen, C. L. White, J. C. Troncoso

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

Hippocampal sclerosis dementia (HSD) is a disease of unknown etiology and pathogenesis. To determine whether HSD cases could be reclassified as variants of frontotemporal dementia (FTD), a heterogeneous group of disorders, 18 brain autopsy cases previously diagnosed as HSD were re-evaluated. In 11 cases, ubiquitinated neuronal inclusions, similar to those of motor neuron disease inclusion dementia (MNDID), were found. Brain levels of soluble and insoluble tau were normal. Most patients with pathologic findings of HSD may actually have the MNDID variant of FTD.

Original language	English (US)
Pages (from-to)	538-542
Number of pages	5
Journal	Neurology
Volume	63
Issue number	3
DOIs	https://doi.org/10.1212/01.WNL.0000129543.46734.C0
State	Published - Aug 10 2004

Funding

ASJC Scopus subject areas

Clinical Neurology

Access to Document

10.1212/01.WNL.0000129543.46734.C0

Cite this

@article{4bedfb209afc426c873e736e38abed49,

title = "Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia",

abstract = "Hippocampal sclerosis dementia (HSD) is a disease of unknown etiology and pathogenesis. To determine whether HSD cases could be reclassified as variants of frontotemporal dementia (FTD), a heterogeneous group of disorders, 18 brain autopsy cases previously diagnosed as HSD were re-evaluated. In 11 cases, ubiquitinated neuronal inclusions, similar to those of motor neuron disease inclusion dementia (MNDID), were found. Brain levels of soluble and insoluble tau were normal. Most patients with pathologic findings of HSD may actually have the MNDID variant of FTD.",

author = "Hatanpaa, {K. J.} and Blass, {D. M.} and O. Pletnikova and Crain, {B. J.} and Bigio, {E. H.} and Hedreen, {J. C.} and White, {C. L.} and Troncoso, {J. C.}",

year = "2004",

month = aug,

day = "10",

doi = "10.1212/01.WNL.0000129543.46734.C0",

language = "English (US)",

volume = "63",

pages = "538--542",

journal = "Neurology",

issn = "0028-3878",

publisher = "Lippincott Williams and Wilkins",

number = "3",

}

TY - JOUR

T1 - Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia

AU - Hatanpaa, K. J.

AU - Blass, D. M.

AU - Pletnikova, O.

AU - Crain, B. J.

AU - Bigio, E. H.

AU - Hedreen, J. C.

AU - White, C. L.

AU - Troncoso, J. C.

PY - 2004/8/10

Y1 - 2004/8/10

N2 - Hippocampal sclerosis dementia (HSD) is a disease of unknown etiology and pathogenesis. To determine whether HSD cases could be reclassified as variants of frontotemporal dementia (FTD), a heterogeneous group of disorders, 18 brain autopsy cases previously diagnosed as HSD were re-evaluated. In 11 cases, ubiquitinated neuronal inclusions, similar to those of motor neuron disease inclusion dementia (MNDID), were found. Brain levels of soluble and insoluble tau were normal. Most patients with pathologic findings of HSD may actually have the MNDID variant of FTD.

AB - Hippocampal sclerosis dementia (HSD) is a disease of unknown etiology and pathogenesis. To determine whether HSD cases could be reclassified as variants of frontotemporal dementia (FTD), a heterogeneous group of disorders, 18 brain autopsy cases previously diagnosed as HSD were re-evaluated. In 11 cases, ubiquitinated neuronal inclusions, similar to those of motor neuron disease inclusion dementia (MNDID), were found. Brain levels of soluble and insoluble tau were normal. Most patients with pathologic findings of HSD may actually have the MNDID variant of FTD.

UR - http://www.scopus.com/inward/record.url?scp=3543049529&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3543049529&partnerID=8YFLogxK

U2 - 10.1212/01.WNL.0000129543.46734.C0

DO - 10.1212/01.WNL.0000129543.46734.C0

M3 - Article

C2 - 15304590

AN - SCOPUS:3543049529

SN - 0028-3878

VL - 63

SP - 538

EP - 542

JO - Neurology

JF - Neurology

IS - 3

ER -

Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia

Abstract

Funding

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this