Motor -cargo interactions: The key to transport specificity

Ryan L. Karcher*, Sean W. Deacon, Vladimir I. Gelfand

*Corresponding author for this work

Research output: Contribution to journalReview article

156 Scopus citations

Abstract

Eukaryotic cells organize their cytoplasm by moving different organelles and macromolecular complexes along microtubules and actin filaments. These movements are powered by numerous motor proteins that must recognize their respective cargoes in order to function. Recently, several proteins that interact with motors have been identified by yeast two-hybrid and biochemical analyses, and their roles in transport are now being elucidated. In several cases, analysis of the binding partners helped to identify new transport pathways, new types of cargo, and transport regulated at the level of motor -cargo binding. We discuss here how different motors of the kinesin, dynein and myosin families recognize their cargo and how motor -cargo interactions are regulated.

Original languageEnglish (US)
Pages (from-to)21-27
Number of pages7
JournalTrends in Cell Biology
Volume12
Issue number1
DOIs
StatePublished - Jan 1 2002

ASJC Scopus subject areas

  • Cell Biology

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