Motor coordination without action potentials in the mammalian spinal cord

Matthew C. Tresch; Ole Kiehn

doi:10.1038/75768

Motor coordination without action potentials in the mammalian spinal cord

Matthew C. Tresch, Ole Kiehn^*

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

143 Scopus citations

Abstract

Coordination of neuronal activity to produce movement is generally thought to depend on spike activity in premotor interneuronal networks. Here we show that even without such activity, the neonatal rat spinal cord could produce a stable motor rhythm mediated by the synchronization of motor neuron oscillations across gap junctions. These rhythms, however, were not coordinated between motor pools in different parts of the spinal cord. We further showed that neural coordination through gap junctions contributed to the fundamental organization and function of spinal motor systems. These results suggest that neural coordination across gap junctions is important in motor-pattern generation in the mammalian spinal cord.

Original language	English (US)
Pages (from-to)	593-599
Number of pages	7
Journal	Nature neuroscience
Volume	3
Issue number	6
DOIs	https://doi.org/10.1038/75768
State	Published - Jun 2000

Funding

This work was supported by the Danish Medical Research Council and the Novo Foundation. M.C.T. is a Postdoctoral Research Fellow supported by the Lundbeck Foundation. We thank Emilio Bizzi, Jorn Hounsgaard, Henrik Jahnsen and Jean-Francois Perrier for reading the manuscript and Hiroshi Nishimaru for suggesting the use of carbenoxolone.

ASJC Scopus subject areas

General Neuroscience

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abstract = "Coordination of neuronal activity to produce movement is generally thought to depend on spike activity in premotor interneuronal networks. Here we show that even without such activity, the neonatal rat spinal cord could produce a stable motor rhythm mediated by the synchronization of motor neuron oscillations across gap junctions. These rhythms, however, were not coordinated between motor pools in different parts of the spinal cord. We further showed that neural coordination through gap junctions contributed to the fundamental organization and function of spinal motor systems. These results suggest that neural coordination across gap junctions is important in motor-pattern generation in the mammalian spinal cord.",

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AB - Coordination of neuronal activity to produce movement is generally thought to depend on spike activity in premotor interneuronal networks. Here we show that even without such activity, the neonatal rat spinal cord could produce a stable motor rhythm mediated by the synchronization of motor neuron oscillations across gap junctions. These rhythms, however, were not coordinated between motor pools in different parts of the spinal cord. We further showed that neural coordination through gap junctions contributed to the fundamental organization and function of spinal motor systems. These results suggest that neural coordination across gap junctions is important in motor-pattern generation in the mammalian spinal cord.

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Motor coordination without action potentials in the mammalian spinal cord

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