Motor cortex activation during treatment may predict therapeutic gains in paretic hand function after stroke

Yun Dong, Bruce H. Dobkin, Steven Y. Cen, Allan D. Wu, Carolee J. Winstein*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

129 Scopus citations

Abstract

BACKGROUND AND PURPOSE - Functional brain imaging after stroke offers insight into motor network adaptations. This exploratory study examined whether motor cortical activation captured during arm-focused therapy can predict paretic hand functional gains. METHODS - Eight hemiparetic patients had serial functional MRI (fMRI) while performing a pinch task before, midway, and after 2 weeks of constraint-induced therapy. The Wolf Motor Function Test (WMFT) was performed before and after intervention. RESULTS - There was a linear reduction in ipsilateral (contralesional) primary motor (M1) activation (voxel counts) across time. The midpoint M1 Laterality Index anticipated post-therapeutic change in time to perform the WMFT. The change in ipsilateral M1 voxel count (pre- to mid-) correlated with the change in mean WMFT time (pre- to post-). CONCLUSIONS - The relationship between brain activation during treatment and functional gains suggests a use for serial fMRI in predicting the success and optimal duration for a focused therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)1552-1555
Number of pages4
JournalStroke
Volume37
Issue number6
DOIs
StatePublished - Jun 2006
Externally publishedYes

Keywords

  • Magnetic resonance imaging
  • Rehabilitation

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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