Motor endplate alterations in schizophrenic patients

John W. Crayton*, Herbert Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

NEUROMUSCULAR pathology has been described in a variety of mentally ill patients, primarily those suffering from schizophrenia or the affective psychosis. Some psychotic patients have increased electrical activity of skeletal muscle at rest1, abnormal electromyograms2, perform poorly on various tests of neuromuscular coordination3, have elevated serum creatine phosphokinase activity during an acute psychotic episode4 and show an increased incidence of morphological abnormalities of skeletal muscle5,6. Such studies have suggested that there may be an alteration of muscle innervation in such patients. We have previously reported that psychotic patients have an increased incidence of branching and sprouting of intramuscular nerve twigs6. We now report significant alterations in the morphology of the nerve terminals at the motor endplate in psychotic patients. This suggests that there may be an abnormality of transmission at neuromuscular synapses in some psychotic patients.

Original languageEnglish (US)
Pages (from-to)658-659
Number of pages2
JournalNature
Volume264
Issue number5587
DOIs
StatePublished - Dec 1 1976

ASJC Scopus subject areas

  • Medicine(all)
  • General

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