Mouse outer hair cells lacking the α9 ACh receptor are motile

David Z.Z. He*, Mary Ann Cheatham, Malini Pearce, Douglas E. Vetter

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Efferent nerve fibers form chemical synapses at the bases of outer hair cells (OHC), with acetylcholine (ACh) being their principal neurotransmitter. The activation of ACh receptors on OHCs is known to influence cochlear function. These efferent effects exhibit an unusual pharmacology and are generally known to be inhibitory. Recent evidence suggests that an ACh receptor subunit, known as α9, plays a dominant role in mediating the olivocochlear neurotransmission to OHCs. In this investigation, we attempt to determine the possible role(s) of the α9 subunit in regulating OHC function by examining OHC electromotility and compound action potentials (CAP) in mice carrying a null mutation for the α9 gene. Results indicate that cochlear sensitivity, based on CAP thresholds, is similar for homozygous mutant and wild-type mice. Electromotility is also present in OHCs, independent of whether the α9 subunit is present or absent.

Original languageEnglish (US)
Pages (from-to)19-25
Number of pages7
JournalDevelopmental Brain Research
Issue number1
StatePublished - Jan 31 2004


  • Acetylcholine
  • Compound action potential
  • Efferent system
  • Electromotility
  • Knockout mouse
  • Nicotinic receptor
  • Olivocochlear bundle
  • Outer hair cell

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology


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