Move to the rhythm: Oscillations in the subthalamic nucleus-external globus pallidus network

Mark D. Bevan*, Peter J. Magill, David Terman, J. Paul Bolam, Charles J. Wilson

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

436 Scopus citations

Abstract

Recent anatomical, physiological and computer modeling studies have revealed that oscillatory processes at the levels of single neurons and neuronal networks in the subthalamic nucleus (STN) and external globus pallidus (GPe) are associated with the operation of the basal ganglia in health and in Parkinson's disease (PD). Autonomous oscillation of STN and GPe neurons underlies tonic activity and is important for synaptic integration, whereas abnormal low-frequency rhythmic bursting in the STN and GPe is characteristic of PD. These recent findings provide further support for the view that the basal ganglia use both the pattern and the rate of neuronal activity to encode information.

Original languageEnglish (US)
Pages (from-to)525-531
Number of pages7
JournalTrends in Neurosciences
Volume25
Issue number10
DOIs
StatePublished - Oct 1 2002

ASJC Scopus subject areas

  • Neuroscience(all)

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