The link between movement abnormalities and psychotic disorders is presumed to reflect common neural mechanisms that influence both motor functions and vulnerability to psychosis. The high-risk or prodromal period preceding psychotic disorders represents both a viable point for intervention and a developmental period with high potential to shed light on etiology. In this chapter, we provide a background for understanding subtypes of movement abnormalities and underlying neurological mechanisms within the context of a neurodevelopmental conceptualization of psychosis and schizophrenia. We use these sections to provide a framework for reviewing and integrating studies of movement abnormalities in high-risk populations. These data are then evaluated to determine the viability of movement abnormalities as a biomarker. Potential directions for movement and biomarker research are evaluated and discussed.
|Original language||English (US)|
|Title of host publication||The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes|
|Subtitle of host publication||Neuropsychological Endophenotypes and Biomarkers|
|Editors||Micheal S Ritsner|
|Number of pages||30|
|State||Published - 2009|