Movement Abnormalities: A Putative Biomarker of Risk for Psychosis

Vijay Anand Mittal, Elaine F. Walker

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The link between movement abnormalities and psychotic disorders is presumed to reflect common neural mechanisms that influence both motor functions and vulnerability to psychosis. The high-risk or prodromal period preceding psychotic disorders represents both a viable point for intervention and a developmental period with high potential to shed light on etiology. In this chapter, we provide a background for understanding subtypes of movement abnormalities and underlying neurological mechanisms within the context of a neurodevelopmental conceptualization of psychosis and schizophrenia. We use these sections to provide a framework for reviewing and integrating studies of movement abnormalities in high-risk populations. These data are then evaluated to determine the viability of movement abnormalities as a biomarker. Potential directions for movement and biomarker research are evaluated and discussed.
Original languageEnglish (US)
Title of host publicationThe Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes
Subtitle of host publicationNeuropsychological Endophenotypes and Biomarkers
EditorsMicheal S Ritsner
PublisherSpringer Netherlands
Pages239-258
Number of pages30
ISBN (Electronic)978-1-4020-9464-4
ISBN (Print)978-1-4020-9463-7
StatePublished - 2009

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