Movement deficits caused by hyperexcitable stretch reflexes in spastic humans

Daniel M. Corcos, Gerald L. Gottlieb*, Richard D. Penn, Barbara Myklebust, Gyan C. Agarwal

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

88 Scopus citations

Abstract

SUMMARY. Spastic patients were instructed to make accurate, rapid ankle dorsiflexion and plantarflexion movements over different distances to a target. Ankle position and surface electromyograms (EMGs) from tibialis anterior (TA) and soleus (SOL) muscles were recorded. In 3 of 8 spastic patients tested, dorsiflexion evoked velocity-dependent activation of the antagonist (SOL) muscle which impeded the movement to the extent that the limb unintentionally reversed movement direction. We propose that this activation is reflex in origin since it (1) is tightly synchronized, (2) has a large peak amplitude, (3) occurs about 50 ms after the initiation of the movement, and (4) is velocity dependent. One of the 3 patients who had reflex-induced antagonist activation in dorsiflexion also demonstrated sustained clonus during plantarflexion. This usually occurred only if the target had been overshot so that the return of the limb stretched the soleus muscle and triggered clonus We conclude that in some patients, hyperactive stretch reflexes cause movement deficits.

Original languageEnglish (US)
Pages (from-to)1043-1058
Number of pages16
JournalBrain
Volume109
Issue number5
DOIs
StatePublished - Oct 1986

ASJC Scopus subject areas

  • Clinical Neurology

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