TY - JOUR
T1 - Moving to Maintain Function in Knee Osteoarthritis
T2 - Evidence From the Osteoarthritis Initiative
AU - Dunlop, Dorothy D.
AU - Semanik, Pamela
AU - Song, Jing
AU - Sharma, Leena
AU - Nevitt, Michael
AU - Jackson, Rebecca
AU - Mysiw, Jerry
AU - Chang, Rowland W.
N1 - Funding Information:
Supported in part by the National Institute for Arthritis and Musculoskeletal Diseases (grant nos. P60-AR48098 , R01-AR055287 , R01-AR054155 ) and the Arthritis Foundation . The Osteoarthritis Initiative (OAI) is a public-private partnership comprised of 5 contracts ( N01-AR-2-2258 , N01-AR-2-2259 , N01-AR-2-2260 , N01-AR-2-2261 , N01-AR-2-2262 ) funded by the National Institutes of Health , a branch of the Department of Health and Human Services , and conducted by the OAI Study Investigators. Private funding partners include Merck Research Laboratories, Novartis Pharmaceuticals Corp, GlaxoSmithKline, and Pfizer, Inc. Private sector funding for the OAI is managed by the Foundation for the National Institutes of Health.
PY - 2010/5
Y1 - 2010/5
N2 - Dunlop DD, Semanik P, Song J, Sharma L, Nevitt M, Mysiw J, Chang RW, for the Osteoarthritis Initiative Investigators. Moving to maintain function in knee osteoarthritis: evidence from the Osteoarthritis Initiative. Objectives: To investigate the association between baseline physical activity and 1-year functional performance in adults with knee osteoarthritis (OA). Design: Prospective cohort study of knee OA development and progression with 1-year follow-up. Setting: Community. Participants: Osteoarthritis Initiative public data on adults with knee OA (n=2274; age, 45-79y) who participated in functional performance assessments (timed 20-m walk and chair stand test) at baseline and 1-year follow-up. Interventions: Not applicable. Main Outcome Measure: A good 1-year performance outcome (separately defined for walk time and chair stand measures) was improvement from baseline quintile or maintenance in the best quintile. Results: Almost 2 in 5 persons with radiographic knee OA improved or maintained high performance at 1 year. Physical activity measured by the Physical Activity Scale for the Elderly (PASE) was significantly associated with good walk rate and chair stand outcomes (odds ratio per 40 units PASE [95% confidence interval]=1.13 [1.13, 1.17] and 1.10 [1.05, 1.15], respectively), as were participation in sports/recreational activities (1.45 [1.23, 1.71] and 1.29 [1.09, 1.51], respectively) and lifestyle activities (1.11 [1.06, 1.16] and 1.09 [1.04, 1.14], respectively). An independent protective relationship for these physical activity measures approached significance after adjusting for sociodemographic and health factors. Older adults reported the least baseline physical activity and least frequent good 1-year outcomes. Conclusions: These findings support public health recommendations to be physically active in order to preserve function for persons with knee OA. Physical activity messages should specifically target older adults whose low activity levels may jeopardize their ability to maintain functional performance.
AB - Dunlop DD, Semanik P, Song J, Sharma L, Nevitt M, Mysiw J, Chang RW, for the Osteoarthritis Initiative Investigators. Moving to maintain function in knee osteoarthritis: evidence from the Osteoarthritis Initiative. Objectives: To investigate the association between baseline physical activity and 1-year functional performance in adults with knee osteoarthritis (OA). Design: Prospective cohort study of knee OA development and progression with 1-year follow-up. Setting: Community. Participants: Osteoarthritis Initiative public data on adults with knee OA (n=2274; age, 45-79y) who participated in functional performance assessments (timed 20-m walk and chair stand test) at baseline and 1-year follow-up. Interventions: Not applicable. Main Outcome Measure: A good 1-year performance outcome (separately defined for walk time and chair stand measures) was improvement from baseline quintile or maintenance in the best quintile. Results: Almost 2 in 5 persons with radiographic knee OA improved or maintained high performance at 1 year. Physical activity measured by the Physical Activity Scale for the Elderly (PASE) was significantly associated with good walk rate and chair stand outcomes (odds ratio per 40 units PASE [95% confidence interval]=1.13 [1.13, 1.17] and 1.10 [1.05, 1.15], respectively), as were participation in sports/recreational activities (1.45 [1.23, 1.71] and 1.29 [1.09, 1.51], respectively) and lifestyle activities (1.11 [1.06, 1.16] and 1.09 [1.04, 1.14], respectively). An independent protective relationship for these physical activity measures approached significance after adjusting for sociodemographic and health factors. Older adults reported the least baseline physical activity and least frequent good 1-year outcomes. Conclusions: These findings support public health recommendations to be physically active in order to preserve function for persons with knee OA. Physical activity messages should specifically target older adults whose low activity levels may jeopardize their ability to maintain functional performance.
KW - Osteoarthritis
KW - Rehabilitation
UR - http://www.scopus.com/inward/record.url?scp=77951278260&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951278260&partnerID=8YFLogxK
U2 - 10.1016/j.apmr.2010.01.015
DO - 10.1016/j.apmr.2010.01.015
M3 - Article
C2 - 20434608
AN - SCOPUS:77951278260
VL - 91
SP - 714
EP - 721
JO - Archives of Physical Medicine and Rehabilitation
JF - Archives of Physical Medicine and Rehabilitation
SN - 0003-9993
IS - 5
ER -
