MR imaging findings of the prostate gland following prostate artery embolization: results from a prospective phase 2 study

Rehan Ali, Ahmed Gabr, Samdeep K. Mouli, Joseph Ralph Kallini, Ahsun Riaz, Ronald Mora, Robert J. Lewandowski, Elias Hohlastos, David D. Casalino, Matthias D. Hofer, Nabeel Hamoui, Frank H. Miller, John Hairston, Riad Salem*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: To assess changes in imaging and volume characteristics of the prostate gland by magnetic resonance (MR) following prostatic artery embolization (PAE) for benign prostate hyperplasia. Methods: With IRB approval, we analyzed prospectively acquired MR data of PAE patients at baseline and 6-month following treatment from 2015 to 2017. We reviewed prostate MRs looking for sequelae of embolization [changes in signal intensity and/or enhancement, infection/inflammation, infarction, edema, and change in intravesical prostatic protrusion (IPP)]. We calculated the total volume (TV) and central gland volumes (CGV) using DynaCAD ® and measured change in volumes. Analyses were performed using SPSS with p < 0.05 considered significant. Results: Forty-three patients (n = 43) met our inclusion criteria. 93% (30/43) and 100% (43/43) showed a decrease in TV and CGV at 6-months respectively. At baseline, median TV was 86 cc (range 29.4–232) and median CGV was 54.4 cc (range 12.9–165.5). Median decrease in TV was 18.2% (CI 13.3–27.2) (p = 0.0001) and median decrease in CGV was 26.7% (CI 20.4–35.9) (p = 0.0001). Thirty-seven percent (16/43) of patients had IPP at baseline; 100% showed a decrease in size of median lobe at follow-up. At 6-month follow-up, 33% (14/43) showed imaging features of infarction, 79% (34/43) had decrease in T2-signal intensity, and 51% (22/43) showed a decrease in enhancement. None had edema, peri-prostatic fat changes or infection/inflammation. Conclusion: PAE causes a statistically significant reduction in the TV and CGV. There is also a reduction of the degree of IPP. Non-specific findings of infarction, decrease in T2-signal, and enhancement were also seen.

Original languageEnglish (US)
Pages (from-to)713-722
Number of pages10
JournalAbdominal Radiology
Volume44
Issue number2
DOIs
StatePublished - Feb 15 2019

Fingerprint

Infarction
Prostate
Arteries
Magnetic Resonance Imaging
Edema
Magnetic Resonance Spectroscopy
Inflammation
Research Ethics Committees
Infection
Hyperplasia
Fats
Therapeutics

Keywords

  • MRI prostate
  • Prospective data
  • Prostate artery embolization
  • Volumetric assessment

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Gastroenterology
  • Urology

Cite this

@article{1f399175c3344dc9b5fb7216dd89d495,
title = "MR imaging findings of the prostate gland following prostate artery embolization: results from a prospective phase 2 study",
abstract = "Purpose: To assess changes in imaging and volume characteristics of the prostate gland by magnetic resonance (MR) following prostatic artery embolization (PAE) for benign prostate hyperplasia. Methods: With IRB approval, we analyzed prospectively acquired MR data of PAE patients at baseline and 6-month following treatment from 2015 to 2017. We reviewed prostate MRs looking for sequelae of embolization [changes in signal intensity and/or enhancement, infection/inflammation, infarction, edema, and change in intravesical prostatic protrusion (IPP)]. We calculated the total volume (TV) and central gland volumes (CGV) using DynaCAD {\circledR} and measured change in volumes. Analyses were performed using SPSS with p < 0.05 considered significant. Results: Forty-three patients (n = 43) met our inclusion criteria. 93{\%} (30/43) and 100{\%} (43/43) showed a decrease in TV and CGV at 6-months respectively. At baseline, median TV was 86 cc (range 29.4–232) and median CGV was 54.4 cc (range 12.9–165.5). Median decrease in TV was 18.2{\%} (CI 13.3–27.2) (p = 0.0001) and median decrease in CGV was 26.7{\%} (CI 20.4–35.9) (p = 0.0001). Thirty-seven percent (16/43) of patients had IPP at baseline; 100{\%} showed a decrease in size of median lobe at follow-up. At 6-month follow-up, 33{\%} (14/43) showed imaging features of infarction, 79{\%} (34/43) had decrease in T2-signal intensity, and 51{\%} (22/43) showed a decrease in enhancement. None had edema, peri-prostatic fat changes or infection/inflammation. Conclusion: PAE causes a statistically significant reduction in the TV and CGV. There is also a reduction of the degree of IPP. Non-specific findings of infarction, decrease in T2-signal, and enhancement were also seen.",
keywords = "MRI prostate, Prospective data, Prostate artery embolization, Volumetric assessment",
author = "Rehan Ali and Ahmed Gabr and Mouli, {Samdeep K.} and Kallini, {Joseph Ralph} and Ahsun Riaz and Ronald Mora and Lewandowski, {Robert J.} and Elias Hohlastos and Casalino, {David D.} and Hofer, {Matthias D.} and Nabeel Hamoui and Miller, {Frank H.} and John Hairston and Riad Salem",
year = "2019",
month = "2",
day = "15",
doi = "10.1007/s00261-018-1757-z",
language = "English (US)",
volume = "44",
pages = "713--722",
journal = "Abdominal Radiology",
issn = "2366-004X",
publisher = "Springer New York",
number = "2",

}

MR imaging findings of the prostate gland following prostate artery embolization : results from a prospective phase 2 study. / Ali, Rehan; Gabr, Ahmed; Mouli, Samdeep K.; Kallini, Joseph Ralph; Riaz, Ahsun; Mora, Ronald; Lewandowski, Robert J.; Hohlastos, Elias; Casalino, David D.; Hofer, Matthias D.; Hamoui, Nabeel; Miller, Frank H.; Hairston, John; Salem, Riad.

In: Abdominal Radiology, Vol. 44, No. 2, 15.02.2019, p. 713-722.

Research output: Contribution to journalArticle

TY - JOUR

T1 - MR imaging findings of the prostate gland following prostate artery embolization

T2 - results from a prospective phase 2 study

AU - Ali, Rehan

AU - Gabr, Ahmed

AU - Mouli, Samdeep K.

AU - Kallini, Joseph Ralph

AU - Riaz, Ahsun

AU - Mora, Ronald

AU - Lewandowski, Robert J.

AU - Hohlastos, Elias

AU - Casalino, David D.

AU - Hofer, Matthias D.

AU - Hamoui, Nabeel

AU - Miller, Frank H.

AU - Hairston, John

AU - Salem, Riad

PY - 2019/2/15

Y1 - 2019/2/15

N2 - Purpose: To assess changes in imaging and volume characteristics of the prostate gland by magnetic resonance (MR) following prostatic artery embolization (PAE) for benign prostate hyperplasia. Methods: With IRB approval, we analyzed prospectively acquired MR data of PAE patients at baseline and 6-month following treatment from 2015 to 2017. We reviewed prostate MRs looking for sequelae of embolization [changes in signal intensity and/or enhancement, infection/inflammation, infarction, edema, and change in intravesical prostatic protrusion (IPP)]. We calculated the total volume (TV) and central gland volumes (CGV) using DynaCAD ® and measured change in volumes. Analyses were performed using SPSS with p < 0.05 considered significant. Results: Forty-three patients (n = 43) met our inclusion criteria. 93% (30/43) and 100% (43/43) showed a decrease in TV and CGV at 6-months respectively. At baseline, median TV was 86 cc (range 29.4–232) and median CGV was 54.4 cc (range 12.9–165.5). Median decrease in TV was 18.2% (CI 13.3–27.2) (p = 0.0001) and median decrease in CGV was 26.7% (CI 20.4–35.9) (p = 0.0001). Thirty-seven percent (16/43) of patients had IPP at baseline; 100% showed a decrease in size of median lobe at follow-up. At 6-month follow-up, 33% (14/43) showed imaging features of infarction, 79% (34/43) had decrease in T2-signal intensity, and 51% (22/43) showed a decrease in enhancement. None had edema, peri-prostatic fat changes or infection/inflammation. Conclusion: PAE causes a statistically significant reduction in the TV and CGV. There is also a reduction of the degree of IPP. Non-specific findings of infarction, decrease in T2-signal, and enhancement were also seen.

AB - Purpose: To assess changes in imaging and volume characteristics of the prostate gland by magnetic resonance (MR) following prostatic artery embolization (PAE) for benign prostate hyperplasia. Methods: With IRB approval, we analyzed prospectively acquired MR data of PAE patients at baseline and 6-month following treatment from 2015 to 2017. We reviewed prostate MRs looking for sequelae of embolization [changes in signal intensity and/or enhancement, infection/inflammation, infarction, edema, and change in intravesical prostatic protrusion (IPP)]. We calculated the total volume (TV) and central gland volumes (CGV) using DynaCAD ® and measured change in volumes. Analyses were performed using SPSS with p < 0.05 considered significant. Results: Forty-three patients (n = 43) met our inclusion criteria. 93% (30/43) and 100% (43/43) showed a decrease in TV and CGV at 6-months respectively. At baseline, median TV was 86 cc (range 29.4–232) and median CGV was 54.4 cc (range 12.9–165.5). Median decrease in TV was 18.2% (CI 13.3–27.2) (p = 0.0001) and median decrease in CGV was 26.7% (CI 20.4–35.9) (p = 0.0001). Thirty-seven percent (16/43) of patients had IPP at baseline; 100% showed a decrease in size of median lobe at follow-up. At 6-month follow-up, 33% (14/43) showed imaging features of infarction, 79% (34/43) had decrease in T2-signal intensity, and 51% (22/43) showed a decrease in enhancement. None had edema, peri-prostatic fat changes or infection/inflammation. Conclusion: PAE causes a statistically significant reduction in the TV and CGV. There is also a reduction of the degree of IPP. Non-specific findings of infarction, decrease in T2-signal, and enhancement were also seen.

KW - MRI prostate

KW - Prospective data

KW - Prostate artery embolization

KW - Volumetric assessment

UR - http://www.scopus.com/inward/record.url?scp=85053066957&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053066957&partnerID=8YFLogxK

U2 - 10.1007/s00261-018-1757-z

DO - 10.1007/s00261-018-1757-z

M3 - Article

C2 - 30196364

AN - SCOPUS:85053066957

VL - 44

SP - 713

EP - 722

JO - Abdominal Radiology

JF - Abdominal Radiology

SN - 2366-004X

IS - 2

ER -