MR-spectroscopic findings in juvenile-onset Huntington's disease

Norman C. Reynolds; Robert W. Prost; Leighton P. Mark; Suja A. Joseph

doi:10.1002/mds.22245

MR-spectroscopic findings in juvenile-onset Huntington's disease

Norman C. Reynolds^*, Robert W. Prost, Leighton P. Mark, Suja A. Joseph

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Seven HD gene positive individuals under the age of 21 years are described with clinical examination and proton-MR-spectroscopy (¹H-MRS) pro.les of the putamen. Despite clinical variability, the predominate ¹HMRS abnormality is elevated glutamate, expressed well beyond the con.nes of the basal ganglia, and low striatal creatine.

Original language	English (US)
Pages (from-to)	1931-1935
Number of pages	5
Journal	Movement Disorders
Volume	23
Issue number	13
DOIs	https://doi.org/10.1002/mds.22245
State	Published - Oct 15 2008

Keywords

Huntington's disease
Juvenile onset
Spectroscopy

ASJC Scopus subject areas

Clinical Neurology
Neurology

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10.1002/mds.22245

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title = "MR-spectroscopic findings in juvenile-onset Huntington's disease",

abstract = "Seven HD gene positive individuals under the age of 21 years are described with clinical examination and proton-MR-spectroscopy (1H-MRS) pro.les of the putamen. Despite clinical variability, the predominate 1HMRS abnormality is elevated glutamate, expressed well beyond the con.nes of the basal ganglia, and low striatal creatine.",

keywords = "Huntington's disease, Juvenile onset, Spectroscopy",

author = "Reynolds, {Norman C.} and Prost, {Robert W.} and Mark, {Leighton P.} and Joseph, {Suja A.}",

year = "2008",

month = oct,

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AU - Reynolds, Norman C.

AU - Prost, Robert W.

AU - Mark, Leighton P.

AU - Joseph, Suja A.

PY - 2008/10/15

Y1 - 2008/10/15

N2 - Seven HD gene positive individuals under the age of 21 years are described with clinical examination and proton-MR-spectroscopy (1H-MRS) pro.les of the putamen. Despite clinical variability, the predominate 1HMRS abnormality is elevated glutamate, expressed well beyond the con.nes of the basal ganglia, and low striatal creatine.

AB - Seven HD gene positive individuals under the age of 21 years are described with clinical examination and proton-MR-spectroscopy (1H-MRS) pro.les of the putamen. Despite clinical variability, the predominate 1HMRS abnormality is elevated glutamate, expressed well beyond the con.nes of the basal ganglia, and low striatal creatine.

KW - Huntington's disease

KW - Juvenile onset

KW - Spectroscopy

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JF - Movement Disorders

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ER -

MR-spectroscopic findings in juvenile-onset Huntington's disease

Abstract

Keywords

ASJC Scopus subject areas

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