MR-spectroscopic findings in juvenile-onset Huntington's disease

Norman C. Reynolds*, Robert W. Prost, Leighton P. Mark, Suja A. Joseph

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Seven HD gene positive individuals under the age of 21 years are described with clinical examination and proton-MR-spectroscopy (1H-MRS) pro.les of the putamen. Despite clinical variability, the predominate 1HMRS abnormality is elevated glutamate, expressed well beyond the con.nes of the basal ganglia, and low striatal creatine.

Original languageEnglish (US)
Pages (from-to)1931-1935
Number of pages5
JournalMovement Disorders
Volume23
Issue number13
DOIs
StatePublished - Oct 15 2008

Keywords

  • Huntington's disease
  • Juvenile onset
  • Spectroscopy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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