TY - JOUR
T1 - MRI features associated with HCC histologic subtypes
T2 - a western American and European bicenter study
AU - Mulé, Sébastien
AU - Serhal, Ali
AU - Pregliasco, Athena Galletto
AU - Nguyen, Jessica
AU - Vendrami, Camila Lopes
AU - Reizine, Edouard
AU - Yang, Guang Yu
AU - Calderaro, Julien
AU - Amaddeo, Giuliana
AU - Luciani, Alain
AU - Miller, Frank H.
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to European Society of Radiology.
PY - 2023/2
Y1 - 2023/2
N2 - Objectives: To evaluate if preoperative MRI can predict the most frequent HCC subtypes in North American and European patients treated with surgical resection. Methods: A total of 119 HCCs in 97 patients were included in the North American group and 191 HCCs in 176 patients were included in the European group. Lesion subtyping was based on morphologic features and immuno-histopathological analysis. Two radiologists reviewed preoperative MRI and evaluated the presence of imaging features including LI-RADS major and ancillary features to identify clinical, biologic, and imaging features associated with the main HCC subtypes. Results: Sixty-four percent of HCCs were conventional. The most frequent subtypes were macrotrabecular-massive (MTM—15%) and steatohepatitic (13%). Necrosis (OR = 3.32; 95% CI: 1.39, 7.89; p =.0064) and observation size (OR = 1.011; 95% CI: 1.0022, 1.019; p =.014) were independent predictors of MTM-HCC. Fat in mass (OR = 15.07; 95% CI: 6.57, 34.57; p <.0001), tumor size (OR = 0.97; 95% CI: 0.96, 0.99; p =.0037), and absence of chronic HCV infection (OR = 0.24; 95% CI: 0.084, 0.67; p =.0068) were independent predictors of steatohepatitic HCC. Independent predictors of conventional HCCs were viral C hepatitis (OR = 3.20; 95% CI: 1.62, 6.34; p =.0008), absence of fat (OR = 0.25; 95% CI: 0.12, 0.52; p =.0002), absence of tumor in vein (OR = 0.34; 95% CI: 0.13, 0.84; p =.020), and higher tumor-to-liver ADC ratio (OR = 1.96; 95% CI: 1.14, 3.35; p =.014) Conclusion: MRI is useful in predicting the most frequent HCC subtypes even in cohorts with different distributions of liver disease etiologies and tumor subtypes which might have future treatment and management implications. Key Points: • Representation of both liver disease etiologies and HCC subtypes differed between the North American and European cohorts of patients. • Retrospective two-center study showed that liver MRI is useful in predicting the most frequent HCC subtypes.
AB - Objectives: To evaluate if preoperative MRI can predict the most frequent HCC subtypes in North American and European patients treated with surgical resection. Methods: A total of 119 HCCs in 97 patients were included in the North American group and 191 HCCs in 176 patients were included in the European group. Lesion subtyping was based on morphologic features and immuno-histopathological analysis. Two radiologists reviewed preoperative MRI and evaluated the presence of imaging features including LI-RADS major and ancillary features to identify clinical, biologic, and imaging features associated with the main HCC subtypes. Results: Sixty-four percent of HCCs were conventional. The most frequent subtypes were macrotrabecular-massive (MTM—15%) and steatohepatitic (13%). Necrosis (OR = 3.32; 95% CI: 1.39, 7.89; p =.0064) and observation size (OR = 1.011; 95% CI: 1.0022, 1.019; p =.014) were independent predictors of MTM-HCC. Fat in mass (OR = 15.07; 95% CI: 6.57, 34.57; p <.0001), tumor size (OR = 0.97; 95% CI: 0.96, 0.99; p =.0037), and absence of chronic HCV infection (OR = 0.24; 95% CI: 0.084, 0.67; p =.0068) were independent predictors of steatohepatitic HCC. Independent predictors of conventional HCCs were viral C hepatitis (OR = 3.20; 95% CI: 1.62, 6.34; p =.0008), absence of fat (OR = 0.25; 95% CI: 0.12, 0.52; p =.0002), absence of tumor in vein (OR = 0.34; 95% CI: 0.13, 0.84; p =.020), and higher tumor-to-liver ADC ratio (OR = 1.96; 95% CI: 1.14, 3.35; p =.014) Conclusion: MRI is useful in predicting the most frequent HCC subtypes even in cohorts with different distributions of liver disease etiologies and tumor subtypes which might have future treatment and management implications. Key Points: • Representation of both liver disease etiologies and HCC subtypes differed between the North American and European cohorts of patients. • Retrospective two-center study showed that liver MRI is useful in predicting the most frequent HCC subtypes.
KW - Hepatocellular carcinoma
KW - Histology subtypes
KW - Liver MRI
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U2 - 10.1007/s00330-022-09085-8
DO - 10.1007/s00330-022-09085-8
M3 - Article
C2 - 35999375
AN - SCOPUS:85136991948
SN - 0938-7994
VL - 33
SP - 1342
EP - 1352
JO - European Radiology
JF - European Radiology
IS - 2
ER -