MRI features of primary rare malignancies of the liver: A report from four university centres

Richard C. Semelka, Nadesan Nimojan, Saman Chandana, Miguel Ramalho, Suzanne L. Palmer, Danielle DeMulder, Carolina Parada Villavicencio, John Woosley, Bonnie L. Garon, Reena C. Jha, Frank H. Miller, Ersan Altun*

*Corresponding author for this work

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Purpose: To determine if rare primary malignancies of the liver may have consistent features on magnetic resonance imaging (MRI). Materials and methods: This IRB-compliant retrospective study reviewed the records from the pathology departments of four university centres over an 11-year period from 2005-2016 to identify rare primary malignant tumours, which were cross-referenced with MRI records. MRI studies of these patients were reviewed to determine if these tumours exhibited consistent and distinctive features. Results: Sixty patients were identified with rare primary liver tumours. The following distinctive features and frequency of occurrence were observed: mixed hepatocellular carcinoma-cholangiocarcinoma showed regions of wash-out in 7/19 of patients; 6/6 of fibrolamellar carcinomas demonstrated large heterogeneous lesions with large heterogeneous central scars; epithelioid haemangioendothelioma larger than 2 cm showed target-like enhancement in late-phase enhancement in 9/13; sarcomas excluding angiosarcoma had central necrosis in 3/9 and haemorrhage in 5/9; angiosarcomas showed centripedal progressive nodular enhancement in 3/6 and showed regions of haemorrhage in 3/6; and 7/7 of primary hepatic lymphomas showed encasement of vessels. Conclusion: Although helpful features for the differentiation of rare primary malignancies of the liver are identified, no MRI features appear to be specific and therefore histopathological confirmation is usually required for definitive diagnosis. Key points: • No MRI features appear to be specific for rare primary liver malignancies. • Haemorrhage is a helpful sign in diagnosis of primary hepatic sarcomas. • Angiosarcomas may show progressive nodular enhancement towards the centre mimicking haemangioma. • Vessel encasement is a helpful sign in diagnosis of primary hepatic lymphoma.

Original languageEnglish (US)
Pages (from-to)1529-1539
Number of pages11
JournalEuropean Radiology
Volume28
Issue number4
DOIs
StatePublished - Apr 1 2018

Keywords

  • Epitheloid haemangioendothelioma
  • Fibrolamellar hepatocellular carcinoma
  • Lymphoma
  • Magnetic resonance imaging
  • Sarcoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Semelka, R. C., Nimojan, N., Chandana, S., Ramalho, M., Palmer, S. L., DeMulder, D., Parada Villavicencio, C., Woosley, J., Garon, B. L., Jha, R. C., Miller, F. H., & Altun, E. (2018). MRI features of primary rare malignancies of the liver: A report from four university centres. European Radiology, 28(4), 1529-1539. https://doi.org/10.1007/s00330-017-5102-7