MRI-guided Biopsy to Correlate Tissue Specimens with MR Elastography Stiffness Readings in Liver Transplants

Ryan B. Perumpail, Josh Levitsky, Yi Wang, Victoria S. Lee, Jennifer Karp, Ning Jin, Guang Yu Yang, Bradley D. Bolster, Saurabh Shah, Sven Zuehlsdorff, Albert A. Nemcek, Andrew C. Larson, Frank H. Miller, Reed A. Omary*

*Corresponding author for this work

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Rationale and Objectives: Magnetic resonance elastography (MRE) can noninvasively measure the stiffness of liver tissue and display this information in anatomic maps. Magnetic resonance imaging (MRI) guidance has not previously been used to biopsy segments of heterogeneous stiffness identified on MRE. Dedicated study of MRE in post-liver transplant patients is also limited. In this study, the ability of real-time MRI to guide biopsies of segments of the liver with different MRE stiffness values in the same post-transplant patient was assessed. Materials and Methods: MRE was performed in 9 consecutive posttransplant patients with history of hepatitis C. Segments of highest and lower stiffness on MRE served as targets for subsequent real-time MRI-guided biopsy using T2-weighted imaging. The ability of MRI-guided biopsy to successfully obtain tissue specimens was assessed. The Wilcoxon signed-rank test was used to compare mean stiffness differences for highest and lower MRE stiffness segments, with α = 0.05. Results: MRI guidance allowed successful sampling of liver tissue for all (18/18) biopsies. There was a statistically significant difference in mean MRE stiffness values between highest (4.61 ± 1.99 kPa) and lower stiffness (3.03 ± 1.75 kPa) (P = .0039) segments biopsied in the 9 posttransplant patients. Conclusion: Real-time MRI can guide biopsy in patients after liver transplantation based on MRE stiffness values. This study supports the use of MRI guidance to sample tissue based on functional information.

Original languageEnglish (US)
Pages (from-to)1121-1126
Number of pages6
JournalAcademic Radiology
Volume19
Issue number9
DOIs
StatePublished - Sep 1 2012

Fingerprint

Image-Guided Biopsy
Elasticity Imaging Techniques
Reading
Magnetic Resonance Imaging
Transplants
Liver
Biopsy
Aptitude
Data Display
Hepatitis C
Nonparametric Statistics
Liver Transplantation

Keywords

  • Image-guided biopsy
  • Liver biopsy
  • Liver transplantation
  • MRI guidance
  • Magnetic resonance elastography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Perumpail, Ryan B. ; Levitsky, Josh ; Wang, Yi ; Lee, Victoria S. ; Karp, Jennifer ; Jin, Ning ; Yang, Guang Yu ; Bolster, Bradley D. ; Shah, Saurabh ; Zuehlsdorff, Sven ; Nemcek, Albert A. ; Larson, Andrew C. ; Miller, Frank H. ; Omary, Reed A. / MRI-guided Biopsy to Correlate Tissue Specimens with MR Elastography Stiffness Readings in Liver Transplants. In: Academic Radiology. 2012 ; Vol. 19, No. 9. pp. 1121-1126.
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title = "MRI-guided Biopsy to Correlate Tissue Specimens with MR Elastography Stiffness Readings in Liver Transplants",
abstract = "Rationale and Objectives: Magnetic resonance elastography (MRE) can noninvasively measure the stiffness of liver tissue and display this information in anatomic maps. Magnetic resonance imaging (MRI) guidance has not previously been used to biopsy segments of heterogeneous stiffness identified on MRE. Dedicated study of MRE in post-liver transplant patients is also limited. In this study, the ability of real-time MRI to guide biopsies of segments of the liver with different MRE stiffness values in the same post-transplant patient was assessed. Materials and Methods: MRE was performed in 9 consecutive posttransplant patients with history of hepatitis C. Segments of highest and lower stiffness on MRE served as targets for subsequent real-time MRI-guided biopsy using T2-weighted imaging. The ability of MRI-guided biopsy to successfully obtain tissue specimens was assessed. The Wilcoxon signed-rank test was used to compare mean stiffness differences for highest and lower MRE stiffness segments, with α = 0.05. Results: MRI guidance allowed successful sampling of liver tissue for all (18/18) biopsies. There was a statistically significant difference in mean MRE stiffness values between highest (4.61 ± 1.99 kPa) and lower stiffness (3.03 ± 1.75 kPa) (P = .0039) segments biopsied in the 9 posttransplant patients. Conclusion: Real-time MRI can guide biopsy in patients after liver transplantation based on MRE stiffness values. This study supports the use of MRI guidance to sample tissue based on functional information.",
keywords = "Image-guided biopsy, Liver biopsy, Liver transplantation, MRI guidance, Magnetic resonance elastography",
author = "Perumpail, {Ryan B.} and Josh Levitsky and Yi Wang and Lee, {Victoria S.} and Jennifer Karp and Ning Jin and Yang, {Guang Yu} and Bolster, {Bradley D.} and Saurabh Shah and Sven Zuehlsdorff and Nemcek, {Albert A.} and Larson, {Andrew C.} and Miller, {Frank H.} and Omary, {Reed A.}",
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Perumpail, RB, Levitsky, J, Wang, Y, Lee, VS, Karp, J, Jin, N, Yang, GY, Bolster, BD, Shah, S, Zuehlsdorff, S, Nemcek, AA, Larson, AC, Miller, FH & Omary, RA 2012, 'MRI-guided Biopsy to Correlate Tissue Specimens with MR Elastography Stiffness Readings in Liver Transplants', Academic Radiology, vol. 19, no. 9, pp. 1121-1126. https://doi.org/10.1016/j.acra.2012.05.011

MRI-guided Biopsy to Correlate Tissue Specimens with MR Elastography Stiffness Readings in Liver Transplants. / Perumpail, Ryan B.; Levitsky, Josh; Wang, Yi; Lee, Victoria S.; Karp, Jennifer; Jin, Ning; Yang, Guang Yu; Bolster, Bradley D.; Shah, Saurabh; Zuehlsdorff, Sven; Nemcek, Albert A.; Larson, Andrew C.; Miller, Frank H.; Omary, Reed A.

In: Academic Radiology, Vol. 19, No. 9, 01.09.2012, p. 1121-1126.

Research output: Contribution to journalArticle

TY - JOUR

T1 - MRI-guided Biopsy to Correlate Tissue Specimens with MR Elastography Stiffness Readings in Liver Transplants

AU - Perumpail, Ryan B.

AU - Levitsky, Josh

AU - Wang, Yi

AU - Lee, Victoria S.

AU - Karp, Jennifer

AU - Jin, Ning

AU - Yang, Guang Yu

AU - Bolster, Bradley D.

AU - Shah, Saurabh

AU - Zuehlsdorff, Sven

AU - Nemcek, Albert A.

AU - Larson, Andrew C.

AU - Miller, Frank H.

AU - Omary, Reed A.

PY - 2012/9/1

Y1 - 2012/9/1

N2 - Rationale and Objectives: Magnetic resonance elastography (MRE) can noninvasively measure the stiffness of liver tissue and display this information in anatomic maps. Magnetic resonance imaging (MRI) guidance has not previously been used to biopsy segments of heterogeneous stiffness identified on MRE. Dedicated study of MRE in post-liver transplant patients is also limited. In this study, the ability of real-time MRI to guide biopsies of segments of the liver with different MRE stiffness values in the same post-transplant patient was assessed. Materials and Methods: MRE was performed in 9 consecutive posttransplant patients with history of hepatitis C. Segments of highest and lower stiffness on MRE served as targets for subsequent real-time MRI-guided biopsy using T2-weighted imaging. The ability of MRI-guided biopsy to successfully obtain tissue specimens was assessed. The Wilcoxon signed-rank test was used to compare mean stiffness differences for highest and lower MRE stiffness segments, with α = 0.05. Results: MRI guidance allowed successful sampling of liver tissue for all (18/18) biopsies. There was a statistically significant difference in mean MRE stiffness values between highest (4.61 ± 1.99 kPa) and lower stiffness (3.03 ± 1.75 kPa) (P = .0039) segments biopsied in the 9 posttransplant patients. Conclusion: Real-time MRI can guide biopsy in patients after liver transplantation based on MRE stiffness values. This study supports the use of MRI guidance to sample tissue based on functional information.

AB - Rationale and Objectives: Magnetic resonance elastography (MRE) can noninvasively measure the stiffness of liver tissue and display this information in anatomic maps. Magnetic resonance imaging (MRI) guidance has not previously been used to biopsy segments of heterogeneous stiffness identified on MRE. Dedicated study of MRE in post-liver transplant patients is also limited. In this study, the ability of real-time MRI to guide biopsies of segments of the liver with different MRE stiffness values in the same post-transplant patient was assessed. Materials and Methods: MRE was performed in 9 consecutive posttransplant patients with history of hepatitis C. Segments of highest and lower stiffness on MRE served as targets for subsequent real-time MRI-guided biopsy using T2-weighted imaging. The ability of MRI-guided biopsy to successfully obtain tissue specimens was assessed. The Wilcoxon signed-rank test was used to compare mean stiffness differences for highest and lower MRE stiffness segments, with α = 0.05. Results: MRI guidance allowed successful sampling of liver tissue for all (18/18) biopsies. There was a statistically significant difference in mean MRE stiffness values between highest (4.61 ± 1.99 kPa) and lower stiffness (3.03 ± 1.75 kPa) (P = .0039) segments biopsied in the 9 posttransplant patients. Conclusion: Real-time MRI can guide biopsy in patients after liver transplantation based on MRE stiffness values. This study supports the use of MRI guidance to sample tissue based on functional information.

KW - Image-guided biopsy

KW - Liver biopsy

KW - Liver transplantation

KW - MRI guidance

KW - Magnetic resonance elastography

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