MRI of hepatic iron deposition in patients with renal transplant

Frank H Miller, Madeleine R. Fisher, William Soper, Richard M. Gore*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Excess hepatic iron deposition was found in five of 15 (33%) renal transplant patients undergoing magnetic resonance (MR) screening for avascular necrosis of the femoral heads. Only one of these patients had overt liver disease. The number of prior blood transfusions was a significant factor for this deposition, whereas the age and sex of the patients, number and type of transplants, histocompatibility alleles (HLA), and years of hemodialysis and of chronic renal failure were not significant etiological factors. Liver/fat intensity ratios of < 0.29 on T 1-weighted images and ratios of < 0.21 on T 2-weighted images and a calculated T 2 value of < 35 ms were the best indicators of iron overload. Renal transplant patients are at great risk for excess hepatic iron deposition and MR imaging is a promising tool for the diagnosis of iron overload in this patient population.

Original languageEnglish (US)
Pages (from-to)229-233
Number of pages5
JournalGastrointestinal Radiology
Volume16
Issue number1
DOIs
StatePublished - Dec 1 1991

Keywords

  • Abdomen, MRI
  • Liver, hemosiderosis
  • Renal transplant, complications

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

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