m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination

Huan Xu; Yulia Dzhashiashvili; Ankeeta Shah; Rejani B. Kunjamma; Yi lan Weng; Benayahu Elbaz; Qili Fei; Joshua S. Jones; Yang I. Li; Xiaoxi Zhuang; Guo li Ming; Chuan He; Brian Popko

doi:10.1016/j.neuron.2019.12.013

m⁶A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination

Huan Xu, Yulia Dzhashiashvili, Ankeeta Shah, Rejani B. Kunjamma, Yi lan Weng, Benayahu Elbaz, Qili Fei, Joshua S. Jones, Yang I. Li, Xiaoxi Zhuang, Guo li Ming, Chuan He, Brian Popko^*

^*Corresponding author for this work

Research output: Contribution to journal › Article

2 Scopus citations

Abstract

Xu et al. show that oligodendrocyte development is associated with dynamic changes in posttranscriptional mRNA methylation. Moreover, they demonstrate that the m⁶A epigenetic RNA mark has considerable impact on the myelinating cell's transcriptome and is essential for normal CNS myelination.

Original language	English (US)
Pages (from-to)	293-309.e5
Journal	Neuron
Volume	105
Issue number	2
DOIs	https://doi.org/10.1016/j.neuron.2019.12.013
State	Published - Jan 22 2020
Externally published	Yes

Keywords

Mettl14
NF155
RNA epigenetic regulation
alternative splicing
m(6)A
mRNA methylation
myelin
oligodendrocyte development
oligodendrocyte precursor cells
oligodendrocytes

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neuron.2019.12.013

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Xu, H., Dzhashiashvili, Y., Shah, A., Kunjamma, R. B., Weng, Y. L., Elbaz, B., Fei, Q., Jones, J. S., Li, Y. I., Zhuang, X., Ming, G. L., He, C., & Popko, B. (2020). m⁶A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination. Neuron, 105(2), 293-309.e5. https://doi.org/10.1016/j.neuron.2019.12.013

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title = "m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination",

abstract = "Xu et al. show that oligodendrocyte development is associated with dynamic changes in posttranscriptional mRNA methylation. Moreover, they demonstrate that the m6A epigenetic RNA mark has considerable impact on the myelinating cell's transcriptome and is essential for normal CNS myelination.",

keywords = "Mettl14, NF155, RNA epigenetic regulation, alternative splicing, m(6)A, mRNA methylation, myelin, oligodendrocyte development, oligodendrocyte precursor cells, oligodendrocytes",

author = "Huan Xu and Yulia Dzhashiashvili and Ankeeta Shah and Kunjamma, {Rejani B.} and Weng, {Yi lan} and Benayahu Elbaz and Qili Fei and Jones, {Joshua S.} and Li, {Yang I.} and Xiaoxi Zhuang and Ming, {Guo li} and Chuan He and Brian Popko",

year = "2020",

month = jan,

day = "22",

doi = "10.1016/j.neuron.2019.12.013",

language = "English (US)",

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m⁶A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination. / Xu, Huan; Dzhashiashvili, Yulia; Shah, Ankeeta; Kunjamma, Rejani B.; Weng, Yi lan; Elbaz, Benayahu; Fei, Qili; Jones, Joshua S.; Li, Yang I.; Zhuang, Xiaoxi; Ming, Guo li; He, Chuan; Popko, Brian.

In: Neuron, Vol. 105, No. 2, 22.01.2020, p. 293-309.e5.

Research output: Contribution to journal › Article

TY - JOUR

T1 - m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination

AU - Xu, Huan

AU - Dzhashiashvili, Yulia

AU - Shah, Ankeeta

AU - Kunjamma, Rejani B.

AU - Weng, Yi lan

AU - Elbaz, Benayahu

AU - Fei, Qili

AU - Jones, Joshua S.

AU - Li, Yang I.

AU - Zhuang, Xiaoxi

AU - Ming, Guo li

AU - He, Chuan

AU - Popko, Brian

PY - 2020/1/22

Y1 - 2020/1/22

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AB - Xu et al. show that oligodendrocyte development is associated with dynamic changes in posttranscriptional mRNA methylation. Moreover, they demonstrate that the m6A epigenetic RNA mark has considerable impact on the myelinating cell's transcriptome and is essential for normal CNS myelination.

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KW - NF155

KW - RNA epigenetic regulation

KW - alternative splicing

KW - m(6)A

KW - mRNA methylation

KW - myelin

KW - oligodendrocyte development

KW - oligodendrocyte precursor cells

KW - oligodendrocytes

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JF - Neuron

SN - 0896-6273

IS - 2

ER -