m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination

Huan Xu; Yulia Dzhashiashvili; Ankeeta Shah; Rejani B. Kunjamma; Yi lan Weng; Benayahu Elbaz; Qili Fei; Joshua S. Jones; Yang I. Li; Xiaoxi Zhuang; Guo li Ming; Chuan He; Brian Popko

doi:10.1016/j.neuron.2019.12.013

m⁶A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination

Huan Xu, Yulia Dzhashiashvili, Ankeeta Shah, Rejani B. Kunjamma, Yi lan Weng, Benayahu Elbaz, Qili Fei, Joshua S. Jones, Yang I. Li, Xiaoxi Zhuang, Guo li Ming, Chuan He, Brian Popko^*

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

114 Scopus citations

Abstract

Xu et al. show that oligodendrocyte development is associated with dynamic changes in posttranscriptional mRNA methylation. Moreover, they demonstrate that the m⁶A epigenetic RNA mark has considerable impact on the myelinating cell's transcriptome and is essential for normal CNS myelination.

Original language	English (US)
Pages (from-to)	293-309.e5
Journal	Neuron
Volume	105
Issue number	2
DOIs	https://doi.org/10.1016/j.neuron.2019.12.013
State	Published - Jan 22 2020

Funding

This work was supported by the National Institutes of Health (NIH) , United States ( R01NS109372 to B.P., R35NS097370 to G.-l.M.), the National Multiple Sclerosis Society, United States ( PP-1603-08106 to B.P.), and the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation, United States to B.P. and G.-l.M. We thank the Genomics facility at the University of Chicago and the Bioinformatics core at the University of Illinois of Chicago for assistance. The Bioinformatics analysis in the project described was performed by the UIC Research Informatics Core, supported in part by National Center for Advancing Translational Sciences ( NCATS), United States, through grant UL1TR002003 . We also thank Dr. Ben Emery for generously providing MYRF antibody for this project and Dr. Vytas Bindokas, Dr. Xiaochang Zhang, Erdong Liu, Gloria Wright, and Ani Solanki for critical advice and assistance.

Keywords

Mettl14
NF155
RNA epigenetic regulation
alternative splicing
m(6)A
mRNA methylation
myelin
oligodendrocyte development
oligodendrocyte precursor cells
oligodendrocytes

ASJC Scopus subject areas

General Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.neuron.2019.12.013

Cite this

@article{95b9d73c838244f58aeb1e9230bacc3a,

title = "m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination",

abstract = "Xu et al. show that oligodendrocyte development is associated with dynamic changes in posttranscriptional mRNA methylation. Moreover, they demonstrate that the m6A epigenetic RNA mark has considerable impact on the myelinating cell's transcriptome and is essential for normal CNS myelination.",

keywords = "Mettl14, NF155, RNA epigenetic regulation, alternative splicing, m(6)A, mRNA methylation, myelin, oligodendrocyte development, oligodendrocyte precursor cells, oligodendrocytes",

author = "Huan Xu and Yulia Dzhashiashvili and Ankeeta Shah and Kunjamma, {Rejani B.} and Weng, {Yi lan} and Benayahu Elbaz and Qili Fei and Jones, {Joshua S.} and Li, {Yang I.} and Xiaoxi Zhuang and Ming, {Guo li} and Chuan He and Brian Popko",

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year = "2020",

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doi = "10.1016/j.neuron.2019.12.013",

language = "English (US)",

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AU - Xu, Huan

AU - Dzhashiashvili, Yulia

AU - Shah, Ankeeta

AU - Kunjamma, Rejani B.

AU - Weng, Yi lan

AU - Elbaz, Benayahu

AU - Fei, Qili

AU - Jones, Joshua S.

AU - Li, Yang I.

AU - Zhuang, Xiaoxi

AU - Ming, Guo li

AU - He, Chuan

AU - Popko, Brian

PY - 2020/1/22

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AB - Xu et al. show that oligodendrocyte development is associated with dynamic changes in posttranscriptional mRNA methylation. Moreover, they demonstrate that the m6A epigenetic RNA mark has considerable impact on the myelinating cell's transcriptome and is essential for normal CNS myelination.

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KW - oligodendrocyte development

KW - oligodendrocyte precursor cells

KW - oligodendrocytes

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