m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination

Huan Xu, Yulia Dzhashiashvili, Ankeeta Shah, Rejani B. Kunjamma, Yi lan Weng, Benayahu Elbaz, Qili Fei, Joshua S. Jones, Yang I. Li, Xiaoxi Zhuang, Guo li Ming, Chuan He, Brian Popko*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Xu et al. show that oligodendrocyte development is associated with dynamic changes in posttranscriptional mRNA methylation. Moreover, they demonstrate that the m6A epigenetic RNA mark has considerable impact on the myelinating cell's transcriptome and is essential for normal CNS myelination.

Original languageEnglish (US)
Pages (from-to)293-309.e5
JournalNeuron
Volume105
Issue number2
DOIs
StatePublished - Jan 22 2020
Externally publishedYes

Keywords

  • Mettl14
  • NF155
  • RNA epigenetic regulation
  • alternative splicing
  • m(6)A
  • mRNA methylation
  • myelin
  • oligodendrocyte development
  • oligodendrocyte precursor cells
  • oligodendrocytes

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Xu, H., Dzhashiashvili, Y., Shah, A., Kunjamma, R. B., Weng, Y. L., Elbaz, B., Fei, Q., Jones, J. S., Li, Y. I., Zhuang, X., Ming, G. L., He, C., & Popko, B. (2020). m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination. Neuron, 105(2), 293-309.e5. https://doi.org/10.1016/j.neuron.2019.12.013