MTOR regulates autophagic flux in the glomerulus

Davide P. Cinà, Tuncer Onay, Aarti Paltoo, Chengjin Li, Yoshiro Maezawa, Javier De Arteaga, Andrea Jurisicova, Susan E. Quaggin*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

14 Scopus citations

Abstract

Sirolimus (rapamycin), an inhibitor of the mechanistic target of rapamycin (MTOR), was originally proposed as an immunosuppressant to prevent rejection of solid organ transplants. There were expectations that MTOR inhibitors would replace nephrotoxic calcineurin inhibitors (CNIs). Despite its potential advantages, evidence that sirolimus causes de novo or worsening proteinuria is unequivocal. Given the well-recognized proteinuric effect of MTOR inhibitors, we were interested in understanding its role in maintaining the glomerular filtration barrier. To investigate this in vivo, we developed a mouse model with a podocyte selective deletion of the Mtor gene (Mtor pod-KO).

Original languageEnglish (US)
Pages (from-to)696-698
Number of pages3
JournalAutophagy
Volume8
Issue number4
DOIs
StatePublished - Apr 2012

Keywords

  • Autolysosomal reformation
  • Autophagy
  • MTOR
  • Podocyte
  • Proteinuria
  • Rapamycin

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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