mTOR signaling mediates effects of common gamma-chain cytokines on T cell proliferation and exhaustion: implications for HIV-1 persistence and cure research

Harry E. Taylor, Nina A. Calantone, Richard T. D'Aquila

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

: Chronic elevation of plasma cytokines is a key feature of HIV infection. The physiological consequences of this response to infection and its role in HIV persistence are not fully understood. Here, we show that common gamma chain (γc)-cytokines induce both proliferation and expression of T cell exhaustion markers in a mammalian target of rapamycin (mTOR)-dependent fashion, suggesting a possible therapeutic target that, if inhibited, could diminish HIV reservoir expansion, persistence, and resistance to immune surveillance.

Original languageEnglish (US)
Pages (from-to)2847-2851
Number of pages5
JournalAIDS (London, England)
Volume32
Issue number18
DOIs
StatePublished - Nov 28 2018

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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