TY - JOUR
T1 - mTOR signaling mediates effects of common gamma-chain cytokines on T cell proliferation and exhaustion
T2 - implications for HIV-1 persistence and cure research
AU - Taylor, Harry E.
AU - Calantone, Nina A.
AU - D'Aquila, Richard T.
N1 - Publisher Copyright:
© 2019 Wolters Kluwer Health, Inc.
PY - 2018/11/28
Y1 - 2018/11/28
N2 - : Chronic elevation of plasma cytokines is a key feature of HIV infection. The physiological consequences of this response to infection and its role in HIV persistence are not fully understood. Here, we show that common gamma chain (γc)-cytokines induce both proliferation and expression of T cell exhaustion markers in a mammalian target of rapamycin (mTOR)-dependent fashion, suggesting a possible therapeutic target that, if inhibited, could diminish HIV reservoir expansion, persistence, and resistance to immune surveillance.
AB - : Chronic elevation of plasma cytokines is a key feature of HIV infection. The physiological consequences of this response to infection and its role in HIV persistence are not fully understood. Here, we show that common gamma chain (γc)-cytokines induce both proliferation and expression of T cell exhaustion markers in a mammalian target of rapamycin (mTOR)-dependent fashion, suggesting a possible therapeutic target that, if inhibited, could diminish HIV reservoir expansion, persistence, and resistance to immune surveillance.
UR - http://www.scopus.com/inward/record.url?scp=85056434580&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85056434580&partnerID=8YFLogxK
U2 - 10.1097/QAD.0000000000001997
DO - 10.1097/QAD.0000000000001997
M3 - Article
C2 - 30234610
AN - SCOPUS:85056434580
SN - 0269-9370
VL - 32
SP - 2847
EP - 2851
JO - AIDS (London, England)
JF - AIDS (London, England)
IS - 18
ER -
