Mucocutaneous granulomatous disease in a patient with Hermansky-Pudlak syndrome

Heather L. Salvaggio, Kristen E. Graeber, Loren E. Clarke, Bethanee J. Schlosser, Seth J. Orlow, Jennie T. Clarke*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

IMPORTANCE Hermansky-Pudlak syndrome (HPS) is a rare genodermatosis characterized by oculocutaneous albinism, platelet dysfunction, and in some patients, pulmonary fibrosis and granulomatous colitis. The granulomatous inflammation in the bowel of patients with HPS can be indistinguishable clinically and histologically from that of Crohn disease (CD); however, mucocutaneous granulomatous lesions have not been considered among the typical skin findings of HPS.

OBSERVATIONS We report a case of an albino woman in her 40s with a history of CD and pulmonary fibrosis who presented with ulcers, plaques, and nodules in the vulva, perineum, inguinal creases, and left axilla. These cutaneous findings had the typical clinical and histologic findings of metastatic cutaneous CD. However, she also had a genetically confirmed diagnosis of HPS.

CONCLUSIONS AND RELEVANCE It is unclear whether our patient's cutaneous findings were due to CD or secondary to HPS. This report reviews the features of HPS and CD, 2 entities characterized by a granulomatous inflammatory reaction pattern but with unique genetic and clinical features, and discusses the possible overlap between the 2 diagnoses.

Original languageEnglish (US)
Pages (from-to)1083-1087
Number of pages5
JournalJAMA dermatology
Volume150
Issue number10
DOIs
StatePublished - Oct 1 2014

ASJC Scopus subject areas

  • Dermatology

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