Mucocutaneous manifestations of the hyper-IgM immunodeficiency syndrome

M. W. Chang, R. Romero, P. R. Scholl, A. S. Paller*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Background: The recurrent pyogenic infections of patients with hyper- IgM syndrome are controlled by intravenous gamma globulin administration, but patients may suffer from early-onset oral ulcerations and warts. Objective: We have characterized the mucocutaneous manifestations associated with this condition to allow physicians to more readily identify it. Methods: Three male patients with the mucocutaneous manifestations of the hyper-IgM syndrome are described. In one, histopathologic examination of the oral mucosal lesion was performed. Results: Recurrent large, painful oral ulcerations can occur that are not necessarily associated with neutropenia nor do they respond to granulocyte colony-stimulating factor administration. Histopathologic examination of an ulcer showed a heavy infiltrate of mixed inflammatory cells. Warts tend to be widespread and resistant to traditional therapy. Conclusion: Physicians should consider this uncommon condition when examining a male patient with severe oral ulcers or recalcitrant widespread warts.

Original languageEnglish (US)
Pages (from-to)191-196
Number of pages6
JournalJournal of the American Academy of Dermatology
Issue number2 I
StatePublished - 1998

ASJC Scopus subject areas

  • Dermatology


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