Multi-ethnic analysis of lipid-associated loci: The NHLBI CARe project

Kiran Musunuru, Simon P.R. Romaine, Guillaume Lettre, James G. Wilson, Kelly A. Volcik, Michael Y. Tsai, Herman A. Taylor, Pamela J. Schreiner, Jerome I. Rotter, Stephen S. Rich, Susan Redline, Bruce M. Psaty, George J. Papanicolaou, Jose M. Ordovas, Kiang Liu, Ronald M. Krauss, Nicole L. Glazer, Stacey B. Gabriel, Myriam Fornage, L. Adrienne CupplesSarah G. Buxbaum, Eric Boerwinkle, Christie M. Ballantyne, Sekar Kathiresan, Daniel J. Rader

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Background: Whereas it is well established that plasma lipid levels have substantial heritability within populations, it remains unclear how many of the genetic determinants reported in previous studies (largely performed in European American cohorts) are relevant in different ethnicities. Methodology/Principal Findings: We tested a set of ~50,000 polymorphisms from ~2,000 candidate genes and genetic loci from genome-wide association studies (GWAS) for association with low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) in 25,000 European Americans and 9,000 African Americans in the National Heart, Lung, and Blood Institute (NHLBI) Candidate Gene Association Resource (CARe). We replicated associations for a number of genes in one or both ethnicities and identified a novel lipid-associated variant in a locus harboring ICAM1. We compared the architecture of genetic loci associated with lipids in both African Americans and European Americans and found that the same genes were relevant across ethnic groups but the specific associated variants at each gene often differed. Conclusions/Significance: We identify or provide further evidence for a number of genetic determinants of plasma lipid levels through population association studies. In many loci the determinants appear to differ substantially between African Americans and European Americans.

Original languageEnglish (US)
Article numbere36473
JournalPloS one
Volume7
Issue number5
DOIs
StatePublished - May 21 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Fingerprint Dive into the research topics of 'Multi-ethnic analysis of lipid-associated loci: The NHLBI CARe project'. Together they form a unique fingerprint.

  • Cite this

    Musunuru, K., Romaine, S. P. R., Lettre, G., Wilson, J. G., Volcik, K. A., Tsai, M. Y., Taylor, H. A., Schreiner, P. J., Rotter, J. I., Rich, S. S., Redline, S., Psaty, B. M., Papanicolaou, G. J., Ordovas, J. M., Liu, K., Krauss, R. M., Glazer, N. L., Gabriel, S. B., Fornage, M., ... Rader, D. J. (2012). Multi-ethnic analysis of lipid-associated loci: The NHLBI CARe project. PloS one, 7(5), [e36473]. https://doi.org/10.1371/journal.pone.0036473