Multi-gram synthesis of a porphyrazine platform for cellular translocation, conjugation to Doxorubicin, and cellular uptake

Evan R. Trivedi, Carl M. Blumenfeld, Todd Wielgos, Sharon Pokropinski, Prasad Dande, Ton T. Hai, Anthony G.M. Barrett, Brian M. Hoffman*

*Corresponding author for this work

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

We report the synthesis of the near infrared (NIR) fluorescent porphyrazine (Pz) 285, with pendant hydroxyl groups, as a non-toxic platform for delivery of conjugated chemotherapeutic agents to tumor cells. Conjugation of Pz 285 to Doxorubicin via an acid labile linker and initial biological studies are reported.

Original languageEnglish (US)
Pages (from-to)5475-5478
Number of pages4
JournalTetrahedron Letters
Volume53
Issue number41
DOIs
StatePublished - Oct 10 2012

Keywords

  • Chemotherapy
  • Porphyrinoid
  • Tetrapyrrole

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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    Trivedi, E. R., Blumenfeld, C. M., Wielgos, T., Pokropinski, S., Dande, P., Hai, T. T., Barrett, A. G. M., & Hoffman, B. M. (2012). Multi-gram synthesis of a porphyrazine platform for cellular translocation, conjugation to Doxorubicin, and cellular uptake. Tetrahedron Letters, 53(41), 5475-5478. https://doi.org/10.1016/j.tetlet.2012.07.087