@article{9364dc171b814bfcb48f38bdfbe026d3,
title = "Multi-gram synthesis of a porphyrazine platform for cellular translocation, conjugation to Doxorubicin, and cellular uptake",
abstract = "We report the synthesis of the near infrared (NIR) fluorescent porphyrazine (Pz) 285, with pendant hydroxyl groups, as a non-toxic platform for delivery of conjugated chemotherapeutic agents to tumor cells. Conjugation of Pz 285 to Doxorubicin via an acid labile linker and initial biological studies are reported.",
keywords = "Chemotherapy, Porphyrinoid, Tetrapyrrole",
author = "Trivedi, {Evan R.} and Blumenfeld, {Carl M.} and Todd Wielgos and Sharon Pokropinski and Prasad Dande and Hai, {Ton T.} and Barrett, {Anthony G.M.} and Hoffman, {Brian M.}",
note = "Funding Information: This work was supported by the Baxter Healthcare Corporation through the Baxter-Northwestern Alliance. Imaging work was performed at the Northwestern University Biological Imaging Facility generously supported by the NU Office for Research. ",
year = "2012",
month = oct,
day = "10",
doi = "10.1016/j.tetlet.2012.07.087",
language = "English (US)",
volume = "53",
pages = "5475--5478",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "41",
}