Multi-institution assessment of the use and risk of cardiovascular computed tomography in pediatric patients with congenital heart disease

Mariana De Oliveira Nunes, Dawn R. Witt*, Susan A. Casey, Cynthia K. Rigsby, Anthony M. Hlavacek, Shahryar M. Chowdhury, Edward D. Nicol, Thomas Semple, John R. Lesser, Katelyn M. Storey, Miranda S. Kunz, Christian W. Schmidt, Larissa I. Stanberry, B. Kelly Han

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Cardiac computed tomography (CT) is increasingly used in pediatric patients with congenital heart disease (CHD). Variability of practice and of comprehensive diagnostic risk across institutions is not known. Methods: Four centers prospectively enrolled consecutive pediatric CHD patients <18 years of age undergoing cardiac CT from January 6, 2017 to 1/30/2020. Patient characteristics, cardiac CT data and comprehensive diagnostic risk were compared by age and institutions. Risk categories included sedation and anesthesia use, vascular access, contrast exposure, cardiovascular medication, adverse events (AEs), and estimated radiation dose. Results: Cardiac CT was performed in 1045 pediatric patients at a median (interquartile range, IQR) age of 1.7 years (0.3, 11.0). The most common indications were arterial abnormalities, suspected coronary artery anomalies, functionally single ventricle heart disease, and tetralogy of Fallot/pulmonary atresia. Sedation was used in 8% and anesthesia in 11% of patients. Peripheral vascular access was utilized for 93%. Median contrast volume was 2 ​ml/kg. Beta blockers were administered in 11% of cases and nitroglycerin in 2% of cases. The median (IQR) total procedural dose length product (DLP) was 20 ​mGy∗cm (10, 50). Sedation, vascular access, contrast exposure, use of cardiovascular medications and radiation dose estimates varied significantly by institution and age (p ​< ​0.001). Seven minor adverse events (0.7%) and no major adverse events were reported. Conclusion: Cardiac CT for CHD is safe in pediatric patients when appropriate CT technology and expertise are available. Scans can be acquired at relatively low radiation exposure with few minor adverse events.

Original languageEnglish (US)
JournalJournal of cardiovascular computed tomography
DOIs
StateAccepted/In press - 2021
Externally publishedYes

Keywords

  • Cardiac computed tomography
  • Comprehensive diagnostic risk
  • Congenital heart disease
  • Dose length product
  • Pediatric

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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