Multi-modal magnetic resonance elastography for noninvasive assessment of ovarian tissue rigidity in vivo

Charles D. Wood, Mayank Vijayvergia, Frank H. Miller, Timothy Carroll, Charles Fasanati, Lonnie D. Shea, L. Catherine Brinson*, Teresa K. Woodruff

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


For centuries, physicians have relied on touch to palpate tissue and detect abnormalities throughout the body. While this time-tested method has provided a simple diagnostic examination for large, superficial abnormalities, it does not permit quantifiable measurements of stiffness in deeper, small organs. Advances in noninvasive imaging to measure tissue rigidity represent important extensions of manual palpation techniques. Tissue fibrosis occurs with age in many organs; in the ovary, it is thought to be a marker of polycystic ovary syndrome and age-related idiopathic infertility, although quantitative assessment of fibrosis in this deep, abdominal tissue has not been possible. We used noninvasive methods to quantify ovarian tissue rigidity and clarify the role of tissue stiffness in reproductive health. With proper validation against accepted standards, noninvasive imaging techniques may become the quantitative counterpart to interior probing palpation methods and invasive (surgical) diagnoses, with applications across many clinical settings, including evaluation of adolescent and young adult ovarian function.

Original languageEnglish (US)
Pages (from-to)295-300
Number of pages6
JournalActa Biomaterialia
StatePublished - Feb 1 2015


  • Alginate
  • Elastography
  • Nanoindentation
  • Ovary
  • Palpation

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology


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