Multi-modality cerebral aneurysm haemodynamic analysis: In vivo 4D flow MRI, in vitro volumetric particle velocimetry and in silico computational fluid dynamics

Melissa C. Brindise, Sean Rothenberger, Benjamin Dickerhoff, Susanne Schnell, Michael Markl, David Saloner, Vitaliy L. Rayz, Pavlos P. Vlachos

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Typical approaches to patient-specific haemodynamic studies of cerebral aneurysms use image-based computational fluid dynamics (CFD) and seek to statistically correlate parameters such as wall shear stress (WSS) and oscillatory shear index (OSI) to risk of growth and rupture. However, such studies have reported contradictory results, emphasizing the need for in-depth multi-modality haemodynamic metric evaluation. In this work, we used in vivo 4D flow MRI data to inform in vitro particle velocimetry and CFD modalities in two patient-specific cerebral aneurysm models (basilar tip and internal carotid artery). Pulsatile volumetric particle velocimetry experiments were conducted, and the particle images were processed using Shake-the-Box, a particle tracking method. Distributions of normalized WSS and relative residence time were shown to be highly yet inconsistently affected by minor flow field and spatial resolution variations across modalities, and specific relationships among these should be explored in future work. Conversely, OSI, a non-dimensional parameter, was shown to be more robust to the varying assumptions, limitations and spatial resolutions of each subject and modality. These results suggest a need for further multi-modality analysis as well as development of non-dimensional haemodynamic parameters and correlation of such metrics to aneurysm risk of growth and rupture.

Original languageEnglish (US)
Article number465
JournalJournal of the Royal Society Interface
Volume16
Issue number158
DOIs
StatePublished - 2019

Keywords

  • 4D flow MRI
  • Cerebral aneurysm
  • Oscillatory shear index
  • Particle image velocimetry
  • Relative residence time
  • Wall shear stress

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering

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