TY - JOUR
T1 - Multibiomarker disease activity score and C-reactive protein in a cross-sectional observational study of patients with rheumatoid arthritis with and without concomitant fibromyalgia
AU - Lee, Yvonne C.
AU - Hackett, James
AU - Frits, Michelle
AU - Iannaccone, Christine K.
AU - Shadick, Nancy A.
AU - Weinblatt, Michael E.
AU - Segurado, Oscar G.
AU - Sasso, Eric H.
N1 - Funding Information:
The authors would like to thank the participants of BRASS. In addition, YL has received grant support from the National Institutes of Health [grant number R01AR064850], and BRASS has received financial support from Crescendo Bioscience, MedImmune and Bristol Myers Squibb. Crescendo Bioscience funded the generation of biomarker data, statistical analysis and the formatting of the manuscript (by Arbor Communications, Inc.).
Publisher Copyright:
© The Author 2015. Published by Oxford University Press on behalf of the British Society for Rheumatology.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Objectives. To examine the association between a multibiomarker disease activity (MBDA) score, CRP and clinical disease activity measures among RA patients with and without concomitant FM. Methods. In an observational cohort of patients with established RA, we performed a cross-sectional analysis comparing MBDA scores with CRP by rank correlation and cross-classification. MBDA scores, CRP and clinical measures of disease activity were compared between patients with RA alone and RA with concomitant FM (RA and FM) by univariate and multivariate analyses. Results. CRP was ≤1.0 mg/dl for 184 of 198 patients (93%). MBDA scores correlated with CRP (r = 0.755, P < 0.001), but were often discordant, being moderate or high for 19%, 55% and 87% of patients with CRP ≤0.1, 0.1 to ≤0.3, or 0.3 to ≤1.0 mg/dl, respectively. Among patients with CRP ≤1.0 mg/dl, swollen joint count (SJC) increased linearly across levels of MBDA score, both with (P = 0.021) and without (P = 0.004) adjustment for CRP, whereas CRP was not associated with SJC. The 28-joint-DAS-CRP, other composite measures, and their non-joint-count component measures were significantly greater for patients with RA and FM (n = 25) versus RA alone (n = 173) (all P ≤ 0.005). MBDA scores and CRP were similar between groups. Conclusion. MBDA scores frequently indicated RA disease activity when CRP did not. Neither one was significantly greater among patients with RA and FM versus RA alone. Thus, MBDA score may be a useful objective measure for identifying RA patients with active inflammation when CRP is low (≤1.0 mg/dl), including RA patients with concomitant FM.
AB - Objectives. To examine the association between a multibiomarker disease activity (MBDA) score, CRP and clinical disease activity measures among RA patients with and without concomitant FM. Methods. In an observational cohort of patients with established RA, we performed a cross-sectional analysis comparing MBDA scores with CRP by rank correlation and cross-classification. MBDA scores, CRP and clinical measures of disease activity were compared between patients with RA alone and RA with concomitant FM (RA and FM) by univariate and multivariate analyses. Results. CRP was ≤1.0 mg/dl for 184 of 198 patients (93%). MBDA scores correlated with CRP (r = 0.755, P < 0.001), but were often discordant, being moderate or high for 19%, 55% and 87% of patients with CRP ≤0.1, 0.1 to ≤0.3, or 0.3 to ≤1.0 mg/dl, respectively. Among patients with CRP ≤1.0 mg/dl, swollen joint count (SJC) increased linearly across levels of MBDA score, both with (P = 0.021) and without (P = 0.004) adjustment for CRP, whereas CRP was not associated with SJC. The 28-joint-DAS-CRP, other composite measures, and their non-joint-count component measures were significantly greater for patients with RA and FM (n = 25) versus RA alone (n = 173) (all P ≤ 0.005). MBDA scores and CRP were similar between groups. Conclusion. MBDA scores frequently indicated RA disease activity when CRP did not. Neither one was significantly greater among patients with RA and FM versus RA alone. Thus, MBDA score may be a useful objective measure for identifying RA patients with active inflammation when CRP is low (≤1.0 mg/dl), including RA patients with concomitant FM.
KW - Biomarkers
KW - C-reactive protein
KW - Disease activity
KW - Fibromyalgia
KW - Multibiomarker
KW - RAPID3
KW - Rheumatoid arthritis
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U2 - 10.1093/rheumatology/kev388
DO - 10.1093/rheumatology/kev388
M3 - Article
C2 - 26608972
AN - SCOPUS:84963741445
SN - 1462-0324
VL - 55
SP - 640
EP - 648
JO - Rheumatology and Rehabilitation
JF - Rheumatology and Rehabilitation
IS - 4
M1 - kev388
ER -